Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02NLI
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| Former ID |
DNC011835
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| Drug Name |
PD-85639
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| Synonyms |
PD-85639; CHEMBL282833; 150034-24-5; CTK8E7452; BDBM50043993; RT-014971; J-008654; N-[3-(2,6-Dimethyl-piperidin-1-yl)-propyl]-2,2-diphenyl-acetamide
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C24H32N2O
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| Canonical SMILES |
CC1CCCC(N1CCCNC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)C
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| InChI |
1S/C24H32N2O/c1-19-11-9-12-20(2)26(19)18-10-17-25-24(27)23(21-13-5-3-6-14-21)22-15-7-4-8-16-22/h3-8,13-16,19-20,23H,9-12,17-18H2,1-2H3,(H,25,27)
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| InChIKey |
BPZBEIHSHWNWTE-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium channel unspecific (NaC) | Target Info | Inhibitor | [1] |
| Voltage-gated sodium channel alpha Nav1.3 (SCN3A) | Target Info | Inhibitor | [2] | |
| Voltage-gated sodium channel alpha Nav1.5 (SCN5A) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Dopaminergic synapse | |||
| Adrenergic signaling in cardiomyocytes | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Interaction between L1 and Ankyrins | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Cardiac Progenitor Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37. | |||
| REF 2 | Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. J Med Chem. 1994 Jan 21;37(2):268-74. | |||
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