Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02JMU
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| Former ID |
DNCL002078
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| Drug Name |
Tasquinimod
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| Synonyms |
TASQ
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| Drug Type |
Small molecular drug
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| Indication | Prostate cancer [ICD-11: 2C82.0; ICD-9: 185] | Phase 3 | [1], [2] | |
| Company |
Active Biotech
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H17F3N2O4
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| Canonical SMILES |
CN1C2=C(C(=CC=C2)OC)C(=C(C1=O)C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)O
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| InChI |
1S/C20H17F3N2O4/c1-24(12-9-7-11(8-10-12)20(21,22)23)18(27)16-17(26)15-13(25(2)19(16)28)5-4-6-14(15)29-3/h4-10,26H,1-3H3
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| InChIKey |
ONDYALNGTUAJDX-UHFFFAOYSA-N
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| CAS Number |
CAS 254964-60-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calgranulin B (S100A9) | Target Info | Modulator | [3] |
| Pathway Interaction Database | Endogenous TLR signaling | |||
| WikiPathways | Vitamin D Receptor Pathway | |||
| IL1 and megakaryotyces in obesity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8098). | |||
| REF 2 | ClinicalTrials.gov (NCT01234311) A Study of Tasquinimod in Men With Metastatic Castrate Resistant Prostate Cancer. U.S. National Institutes of Health. | |||
| REF 3 | Mechanisms of action of tasquinimod on the tumour microenvironment. Cancer Chemother Pharmacol. 2014; 73(1): 1-8. | |||
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