Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02IZN
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| Former ID |
DIB008361
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| Drug Name |
ON-123
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| Synonyms |
ON-1231320; ON-123 series (cancer); Sulfonyl pyridopyrimidines (cancer), Onconova; ON-123 series (cancer), Onconova; Plk-2 inhibitors (cancer), Onconova; Polo-like kinase 2 inhibitors (cancer), Onconova
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [1] | |
| Company |
Onconova Therapeutics Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polo-like kinase 2 (PLK2) | Target Info | Inhibitor | [1] |
| KEGG Pathway | FoxO signaling pathway | |||
| NetPath Pathway | IL1 Signaling Pathway | |||
| TSH Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| TCR Signaling Pathway | ||||
| Pathway Interaction Database | PLK2 and PLK4 events | |||
| Polo-like kinase signaling events in the cell cycle | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2169). | |||
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