Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02IVU
|
|||
| Former ID |
DNC008859
|
|||
| Drug Name |
CACOSPONGIONOLIDE
|
|||
| Synonyms |
cacospongionolide; CHEMBL480681
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C25H36O4
|
|||
| Canonical SMILES |
CC1CCC23CC2(CCCC3C1(C)CCC4=CCC(OC4)C5=CC(=O)OC5O)C
|
|||
| InChI |
1S/C25H36O4/c1-16-8-12-25-15-23(25,2)10-4-5-20(25)24(16,3)11-9-17-6-7-19(28-14-17)18-13-21(26)29-22(18)27/h6,13,16,19-20,22,27H,4-5,7-12,14-15H2,1-3H3/t16-,19+,20+,22+,23-,24-,25-/m0/s1
|
|||
| InChIKey |
FPUWYDSKOKLTDH-FRMRWZTPSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Group IIA phospholipase A2 (GIIA sPLA2) | Target Info | Inhibitor | [1] |
| Phospholipase A2 (PLA2G1B) | Target Info | Inhibitor | [1] | |
| BioCyc | Phospholipases | |||
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Ether lipid metabolism | ||||
| Arachidonic acid metabolism | ||||
| Linoleic acid metabolism | ||||
| alpha-Linolenic acid metabolism | ||||
| Metabolic pathways | ||||
| Ras signaling pathway | ||||
| Vascular smooth muscle contraction | ||||
| Pancreatic secretion | ||||
| Fat digestion and absorption | ||||
| Pathway Interaction Database | Glypican 1 network | |||
| Fc-epsilon receptor I signaling in mast cells | ||||
| Reactome | Acyl chain remodelling of PC | |||
| Acyl chain remodelling of PE | ||||
| Acyl chain remodelling of PI | ||||
| WikiPathways | Cardiac Hypertrophic Response | |||
| Glycerophospholipid biosynthesis | ||||
| Glycerophospholipid Biosynthetic Pathway | ||||
| Spinal Cord Injury | ||||
| Eicosanoid Synthesis | ||||
| MicroRNAs in cardiomyocyte hypertrophy | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.