Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02INZ
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| Former ID |
DNC000273
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| Drug Name |
BABIM
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| Synonyms |
BABIM; Bis(5-amidino-2-benzimidazolyl)methane; 74733-75-8; CHEMBL99951; 1H-Benzimidazole-5-carboximidamide, 2,2'-methylenebis-; 1xug; 1c1v; AC1L1DKB; SCHEMBL65730; AC1Q1U90; CTK5E0415; BDBM16127; DTXSID60225717; AIDS007118; ZINC3871731; AKOS028112598; Bis(5-amidino-1H-benzimidazole-2-yl)methane; 1H-Benzimidazole-6-carboximidamide,2,2'-methylenebis-; 2,2 -methanediylbis(1H-benzimidazole-6-carboximidamide); 2-[(5-carbamimidoyl-1H-benzimidazol-2-yl)methyl]-1H-benzimidazole-5-carboxamidine
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Terminated | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H16N8
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| Canonical SMILES |
C1=CC2=C(C=C1C(=N)N)NC(=N2)CC3=NC4=C(N3)C=C(C=C4)C(=N)N
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| InChI |
1S/C17H16N8/c18-16(19)8-1-3-10-12(5-8)24-14(22-10)7-15-23-11-4-2-9(17(20)21)6-13(11)25-15/h1-6H,7H2,(H3,18,19)(H3,20,21)(H,22,24)(H,23,25)
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| InChIKey |
QZKOOEFIMWKZPK-UHFFFAOYSA-N
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| CAS Number |
CAS 74733-75-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
602704, 820516, 820517, 820518, 820519, 8151600, 14826768, 15347907, 26683763, 29221553, 46391607, 46393598, 46516386, 50414014, 57321296, 81059609, 81059610, 81059611, 81059612, 103317645, 103814594, 103854597, 103936784, 104300440, 117373875, 129097177, 134339739, 135082485, 137022513, 140305138, 140323957, 160964938, 162908732, 226446832, 246841763
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tryptase alpha/beta-1 (Tryptase) | Target Info | Inhibitor | [2] |
| Reactome | Activation of Matrix Metalloproteinases | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010022) | |||
| REF 2 | Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96. | |||
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