Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02GNH
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| Drug Name |
Quinazoline derivative 9
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| Synonyms |
PMID26161698-Compound-47
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65; ICD-10: C50, C79.51] | Phase 1 | [1] | |
| Company |
SENEX BIOTECHNOLOGY INC
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| Structure |
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Download2D MOL |
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| Formula |
C27H26N6O
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| Canonical SMILES |
CN1CCN(CC1)C(=O)C2=CC3=C(C=C2)C=C(C=C3)CCNC4=NC=NC5=C4C=C(C=C5)C#N
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| InChI |
1S/C27H26N6O/c1-32-10-12-33(13-11-32)27(34)23-6-5-21-14-19(2-4-22(21)16-23)8-9-29-26-24-15-20(17-28)3-7-25(24)30-18-31-26/h2-7,14-16,18H,8-13H2,1H3,(H,29,30,31)
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| InChIKey |
VNADJTWHOAMTLY-UHFFFAOYSA-N
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| CAS Number |
CAS 1449228-40-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | MEK kinase kinase 2 (MAP4K2) | Target Info | Inhibitor | [2] |
| SPS1/STE20-related protein kinase YSK4 (YSK4) | Target Info | Inhibitor | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03065010) Study of BCD-115 in Women With ER(+) HER2(-) Local Advanced and Metastatic Breast Cancer. U.S. National Institutes of Health. | |||
| REF 2 | Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. | |||
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