Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02ESL
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| Former ID |
DIB009461
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| Drug Name |
ON-01210.Na
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| Synonyms |
Ex-RAD; Tyrosine kinase inhibitor (radiation protection), Onconova; ON-01210.Na (oral, radiation sickness); ON-01210.Na (oral, radiation sickness), Onconova; ON-01210.Na (sc, radiation sickness), Onconova Therapeutics
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| Drug Type |
Small molecular drug
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| Indication | Acute radiation syndrome [ICD-11: NF00; ICD-10: T66; ICD-9: 990] | Phase 1 | [1] | |
| Radiation syndrome [ICD-11: NF00; ICD-10: T66; ICD-9: 990] | Phase 1 | [2] | ||
| Company |
Onconova Therapeutics Inc
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| Structure |
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Download2D MOL |
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| Formula |
C16H12ClNaO4S
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| Canonical SMILES |
C1=CC(=CC=C1CS(=O)(=O)C=CC2=CC=C(C=C2)C(=O)[O-])Cl.[Na+]
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| InChI |
1S/C16H13ClO4S.Na/c17-15-7-3-13(4-8-15)11-22(20,21)10-9-12-1-5-14(6-2-12)16(18)19;/h1-10H,11H2,(H,18,19);/q;+1/p-1/b10-9+;
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| InChIKey |
PRFBWBYKWZVQJF-RRABGKBLSA-M
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| CAS Number |
CAS 922139-31-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | PI3K/AKT/mTOR pathway (PAm pathway) | Target Info | Inhibitor | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020974) | |||
| REF 3 | ON01210.Na (Ex-RAD ) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355. | |||
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