Drug Information
Drug General Information | Top | |||
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Drug ID |
D02ENG
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Former ID |
DNC000361
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Drug Name |
BVT.2733
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Synonyms |
CHEMBL553071; AC1OCFOV; 376641-65-5; SCHEMBL5692696; MolPort-042-665-756; 3-chloro-2-methyl-N-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-thiazol-2-yl]benzenesulfonamide hydrochloride
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Drug Type |
Small molecular drug
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Indication | Lupus [ICD-11: 4A40; ICD-9: 583.81] | Phase 3 | [1] | |
Systemic lupus erythematosus [ICD-11: 4A40.0; ICD-9: 710] | Phase 3 | [1] | ||
Myasthenia gravis [ICD-11: 8C6Y; ICD-10: G70.0; ICD-9: 358] | Phase 2 | [1] | ||
Non-insulin dependent diabetes [ICD-11: 5A11] | Investigative | [2] | ||
Structure |
Download2D MOL |
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Formula |
C17H21ClN4O3S2
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Canonical SMILES |
CC1=C(C=CC=C1Cl)S(=O)(=O)NC2=NC(=CS2)CC(=O)N3CCN(CC3)C
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InChI |
1S/C17H21ClN4O3S2/c1-12-14(18)4-3-5-15(12)27(24,25)20-17-19-13(11-26-17)10-16(23)22-8-6-21(2)7-9-22/h3-5,11H,6-10H2,1-2H3,(H,19,20)
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InChIKey |
YDPRNGAPPNPYQQ-UHFFFAOYSA-N
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CAS Number |
CAS 376640-41-4
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) | Target Info | Inhibitor | [2] |
KEGG Pathway | Steroid hormone biosynthesis | |||
Metabolism of xenobiotics by cytochrome P450 | ||||
Metabolic pathways | ||||
Chemical carcinogenesis | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
FSH Signaling Pathway | ||||
Pathwhiz Pathway | Steroidogenesis | |||
Reactome | Glucocorticoid biosynthesis | |||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
Metabolism of steroid hormones and vitamin D | ||||
Glucocorticoid & Mineralcorticoid Metabolism |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 2 | Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology. 2003 Nov;144(11):4755-62. |
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