Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02DWK
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| Former ID |
DIB004593
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| Drug Name |
2-hydroxyoleic acid
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| Synonyms |
2R-hydroxy-oleic acid; 2R-hydroxy-9Z-octadecenoic acid; R-Hydroxy-olsaure; (R)-2-Hydroxyoleic acid; SCHEMBL378127; ZINC14210872; LMFA02000056; UNII-OSV3KVO1BT component JBSOOFITVPOOSY-DOOKAGJSSA-N
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Phase 1/2 | [1] | |
| Company |
Bridge BioResearch International Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H34O3
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| Canonical SMILES |
CCCCCCCCC=CCCCCCCC(C(=O)O)O
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| InChI |
1S/C18H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h9-10,17,19H,2-8,11-16H2,1H3,(H,20,21)/b10-9-
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| InChIKey |
JBSOOFITVPOOSY-KTKRTIGZSA-N
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| CAS Number |
CAS 56472-29-8
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:143096
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sphingomyelin synthase (SMS) | Target Info | Modulator | [1], [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells. J Lipid Res. 2013 May;54(5):1457-65. | |||
| REF 2 | Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19569-74. | |||
| REF 3 | The hypotensive drug 2-hydroxyoleic acid modifies the structural properties of model membranes. Mol Membr Biol. 2004 Jul-Aug;21(4):261-8. | |||
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