Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02DMW
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| Former ID |
DIB005589
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| Drug Name |
S-1360
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| Synonyms |
GW-810781; 810781
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| Drug Type |
Small molecular drug
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Phase 2 | [1] | |
| Company |
Shionogi & Co Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H12FN3O3
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| Canonical SMILES |
C1=CC(=CC=C1CC2=CC=C(O2)C(=O)C=C(C3=NC=NN3)O)F
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| InChI |
1S/C16H12FN3O3/c17-11-3-1-10(2-4-11)7-12-5-6-15(23-12)13(21)8-14(22)16-18-9-19-20-16/h1-6,8-9,22H,7H2,(H,18,19,20)/b14-8-
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| InChIKey |
HFHDGHOGHWXXDT-ZSOIEALJSA-N
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| CAS Number |
CAS 280571-30-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Integrase (HIV IN) | Target Info | Inhibitor | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00046332) A Study Comparing 4 Doses Of GW810781 Versus Placebo In HIV-Infected Patients. U.S. National Institutes of Health. | |||
| REF 2 | HIV-1 integrase inhibitors: an emerging clinical reality. Drugs R D. 2007;8(3):155-68. | |||
| REF 3 | Calculation of binding energy using BLYP/MM for the HIV-1 integrase complexed with the S-1360 and two analogues. Bioorg Med Chem. 2007 Jun 1;15(11):3818-24. | |||
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