Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02DHU
|
|||
| Former ID |
DIB008422
|
|||
| Drug Name |
SKF-81297
|
|||
| Synonyms |
SKF 81297 hydrochloride
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Terminated | [1], [2] | |
| Company |
SmithKline Beecham Pharmaceuticals
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C16H16ClNO2
|
|||
| Canonical SMILES |
C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=CC=C3
|
|||
| InChI |
1S/C16H16ClNO2/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20/h1-5,8,13,18-20H,6-7,9H2
|
|||
| InChIKey |
GHWJEDJMOVUXEC-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 71636-61-8
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
5589359, 7980604, 8151035, 14824803, 24439563, 26756523, 47291339, 47365431, 48259476, 50065113, 50104853, 57320818, 75221142, 85209307, 90341484, 103436438, 103805422, 104297098, 117460298, 124750283, 124881364, 126407017, 127956269, 134222361, 135065772, 135651051, 136352382, 137010203, 162223780, 162903081, 179293662, 179574135, 184587757, 224813544, 226727478, 249801642
|
|||
| ChEBI ID |
CHEBI:91517
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine D1 receptor (D1R) | Target Info | Modulator | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Dopaminergic synapse | ||||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Morphine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Dopamine receptor mediated signaling pathway | |||
| Pathwhiz Pathway | Dopamine Activation of Neurological Reward System | |||
| Reactome | Dopamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Hypothetical Network for Drug Addiction | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Genes and (Common) Pathways Underlying Drug Addiction | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 938). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004119) | |||
| REF 3 | Dopamine D1 receptor involvement in the discriminative-stimulus effects of SKF 81297 in squirrel monkeys. J Pharmacol Exp Ther. 1993 Nov;267(2):765-75. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.