Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02CPP
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| Former ID |
DNCL003781
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| Drug Name |
Vonoprazan
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| Synonyms |
TAK-438
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| Drug Type |
Small molecular drug
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| Indication | Helicobacter infection [ICD-11: DA42-DA63; ICD-10: B96.81; ICD-9: 41.86] | Approved | [1] | |
| Gastroesophageal reflux disease [ICD-11: DA22.Z] | Phase 3 | [2] | ||
| Company |
Takeda
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H20FN3O6S
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| Canonical SMILES |
CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=CC(=O)O)C(=O)O
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| InChI |
1S/C17H16FN3O2S.C4H4O4/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14;5-3(6)1-2-4(7)8/h2-9,11-12,19H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
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| InChIKey |
ROGSHYHKHPCCJW-WLHGVMLRSA-N
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| CAS Number |
CAS 881681-01-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gastric H(+)/K(+) ATPase (Proton pump) | Target Info | Modulator | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2008 | |||
| REF 2 | ClinicalTrials.gov (NCT02388724) Efficacy and Safety of Oral Once-Daily Vonoprazan (TAK-438) in Patients With Erosive Esophagitis. U.S. National Institutes of Health. | |||
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