Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02AYI
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| Former ID |
DNC009583
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| Drug Name |
2-(4-phenoxyphenoxy)ethanamine
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| Synonyms |
2-(4-phenoxyphenoxy)ethanamine; CHEMBL472386; 2-(4-Phenoxyphenoxy)Ethylamine; 72490-14-3; SCHEMBL9486899; SCHEMBL4653229; CTK2H2396; DTXSID40452640; FBLANPWAVFBRNS-UHFFFAOYSA-N; 2-[(p-phenoxy)phenoxy]ethylamine; Ethanamine, 2-(4-phenoxyphenoxy)-; ZINC11945831; BDBM50246062
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H15NO2
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| Canonical SMILES |
C1=CC=C(C=C1)OC2=CC=C(C=C2)OCCN
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| InChI |
1S/C14H15NO2/c15-10-11-16-12-6-8-14(9-7-12)17-13-4-2-1-3-5-13/h1-9H,10-11,15H2
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| InChIKey |
FBLANPWAVFBRNS-UHFFFAOYSA-N
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| CAS Number |
CAS 72490-14-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Group IIA phospholipase A2 (GIIA sPLA2) | Target Info | Inhibitor | [1] |
| Leukotriene A-4 hydrolase (LTA4H) | Target Info | Inhibitor | [2] | |
| BioCyc | Phospholipases | |||
| Leukotriene biosynthesis | ||||
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Ether lipid metabolism | ||||
| Arachidonic acid metabolism | ||||
| Linoleic acid metabolism | ||||
| alpha-Linolenic acid metabolism | ||||
| Metabolic pathways | ||||
| Ras signaling pathway | ||||
| Vascular smooth muscle contraction | ||||
| Pancreatic secretion | ||||
| Fat digestion and absorption | ||||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| Pathway Interaction Database | Glypican 1 network | |||
| Reactome | Acyl chain remodelling of PC | |||
| Acyl chain remodelling of PE | ||||
| Acyl chain remodelling of PI | ||||
| WikiPathways | Cardiac Hypertrophic Response | |||
| Glycerophospholipid biosynthesis | ||||
| Glycerophospholipid Biosynthetic Pathway | ||||
| Spinal Cord Injury | ||||
| Eicosanoid Synthesis | ||||
| MicroRNAs in cardiomyocyte hypertrophy | ||||
| Arachidonic acid metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8. | |||
| REF 2 | Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. | |||
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