Drug Information
Drug General Information | Top | |||
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Drug ID |
D01ZIP
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Former ID |
DNC005461
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Drug Name |
N-[5-(2-Ethyl-phenyl)-furan-2-carbonyl]-guanidine
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Synonyms |
CHEMBL372051; N-[5-(2-Ethyl-phenyl)-furan-2-carbonyl]-guanidine; SCHEMBL4939618
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C14H15N3O2
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Canonical SMILES |
CCC1=CC=CC=C1C2=CC=C(O2)C(=O)N=C(N)N
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InChI |
1S/C14H15N3O2/c1-2-9-5-3-4-6-10(9)11-7-8-12(19-11)13(18)17-14(15)16/h3-8H,2H2,1H3,(H4,15,16,17,18)
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InChIKey |
CCKFOHBQWASBLB-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Sodium/hydrogen exchanger 1 (SLC9A1) | Target Info | Inhibitor | [1] |
KEGG Pathway | cAMP signaling pathway | |||
Cardiac muscle contraction | ||||
Adrenergic signaling in cardiomyocytes | ||||
Regulation of actin cytoskeleton | ||||
Thyroid hormone signaling pathway | ||||
Salivary secretion | ||||
Gastric acid secretion | ||||
Pancreatic secretion | ||||
Bile secretion | ||||
Proteoglycans in cancer | ||||
Pathway Interaction Database | Endothelins | |||
RhoA signaling pathway | ||||
ErbB1 downstream signaling | ||||
Signaling mediated by p38-alpha and p38-beta | ||||
Reactome | Hyaluronan uptake and degradation | |||
WikiPathways | Regulation of Actin Cytoskeleton | |||
G Protein Signaling Pathways | ||||
Glycosaminoglycan metabolism | ||||
Osteoclast Signaling |
References | Top | |||
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REF 1 | (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. |
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