Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01ZCI
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| Former ID |
DIB020711
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| Drug Name |
phosphatidyl (3,5) inositol biphosphate
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| Synonyms |
phosphatidylinositol 3,5-bisphosphate; PI(3,5)P2
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C41H81O19P3
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| Canonical SMILES |
CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)OP(=O)(O)O)O)OP(=O)(O)O)O)OC(=O)CCCCCCCCCCCCCCC
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| InChI |
1S/C41H81O19P3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)55-31-33(57-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)32-56-63(53,54)60-41-37(45)39(58-61(47,48)49)36(44)40(38(41)46)59-62(50,51)52/h33,36-41,44-46H,3-32H2,1-2H3,(H,53,54)(H2,47,48,49)(H2,50,51,52)/t33-,36?,37-,38-,39-,40+,41?/m1/s1
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| InChIKey |
UZMPYXSDDZXMAI-OHKKONBVSA-N
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| CAS Number |
CAS 214282-36-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:82954
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Mucolipin-1 (TRPML1) | Target Info | Activator | [2] |
| Two pore calcium channel protein 1 (TPC1) | Target Info | Activator | [3] | |
| Two pore calcium channel protein 2 (TPC2) | Target Info | Activator | [4] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2794). | |||
| REF 2 | PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun. 2010 Jul 13;1:38. | |||
| REF 3 | The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nat Chem Biol. 2014 Jun;10(6):463-9. | |||
| REF 4 | TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 2012 Oct 12;151(2):372-83. | |||
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