Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01XVX
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| Former ID |
DIB003628
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| Drug Name |
CC-220
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| Synonyms |
AC1OEW2H; NPD6561; MCULE-9299015048; BCP9000573; BCP0726000266
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| Drug Type |
Small molecular drug
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| Indication | Sarcoidosis [ICD-11: 4B20.5; ICD-10: D86.3; ICD-9: 135] | Phase 2 | [1] | |
| Systemic lupus erythematosus [ICD-11: 4A40.0; ICD-9: 710] | Phase 2 | [2] | ||
| Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0] | Phase 1 | [3] | ||
| Structure |
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Download2D MOL |
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| Formula |
C25H27N3O5
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| Canonical SMILES |
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5
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| InChI |
1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
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| InChIKey |
IXZOHGPZAQLIBH-NRFANRHFSA-N
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| CAS Number |
CAS 1323403-33-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein cereblon (CRBN) | Target Info | Inhibitor | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02185040) A Pilot Study of CC-220 to Treat Systemic Lupus Erythematosus.. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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