Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01WZG
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| Former ID |
DIB014044
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| Drug Name |
Creatine ALS-08
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| Synonyms |
Creatine; ALS-02; ALS-05; ALS-08; HD-02; PD-02; PD-04; PD-06; Creatine (ALS), Avicena; Creatine (amyotrophic lateral sclerosis), Avicena; PD-01, Avicena; AL-02 (ALS), Avicena; AL-08 (ALS), Avicena; Creatine (Huntington's disease), Avicena; Creatine (Parkinson's disease), Avicena
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| Drug Type |
Small molecular drug
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| Indication | Motor neurone disease [ICD-11: 8B60; ICD-10: G12.2; ICD-9: 335.2] | Phase 3 | [1], [2] | |
| Company |
Avicena Group Inc; Avicena
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| Structure |
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Download2D MOL |
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| Formula |
C4H9N3O2
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| Canonical SMILES |
CN(CC(=O)O)C(=N)N
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| InChI |
1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)
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| InChIKey |
CVSVTCORWBXHQV-UHFFFAOYSA-N
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| CAS Number |
CAS 57-00-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3594, 74369, 831847, 855190, 3139605, 4947662, 7886773, 8137931, 8143593, 8150697, 10527747, 15170675, 24438948, 24857517, 24892273, 46504868, 50800367, 56311485, 56311510, 56312867, 56365626, 57320315, 57410916, 81065541, 85164924, 87457515, 87565524, 88828666, 93620616, 102851574, 103187076, 104295252, 117475574, 117475575, 125292581, 125326843, 125353363, 126522989, 126677726, 127265156, 127265157, 127265158, 127265159, 127265160, 127265161, 127684899, 131999723, 134970539, 136961253, 137003471
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| ChEBI ID |
CHEBI:16919
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Mitochondrial function (MF) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4496). | |||
| REF 2 | The therapeutic role of creatine in Huntington's disease. Pharmacol Ther. 2005 Nov;108(2):193-207. | |||
| REF 3 | Creatine for Parkinson's disease. Cochrane Database Syst Rev. 2014 Jun 17;6:CD009646. | |||
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