Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01WGJ
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| Former ID |
DNC002527
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| Drug Name |
Daidzin
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| Synonyms |
AC1N4RYA; MLS000563445; SCHEMBL3423674; CHEMBL115316; KYQZWONCHDNPDP-UHFFFAOYSA-N; HMS3604G15; HMS3348J07; HMS2194K16; AKOS024284500; AC-6036; MCULE-3802707688; SMR000232339; ST077114; SR-01000721602; SR-01000721602-3; I06-0227; 3-(4-hydroxyphenyl)-7-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one; 4H-1-Benzopyran-4-one, 7-(.beta.-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-; 3-(4-hydroxyphenyl)-7-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H20O9
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| Canonical SMILES |
C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O)O
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| InChI |
1S/C21H20O9/c22-8-16-18(25)19(26)20(27)21(30-16)29-12-5-6-13-15(7-12)28-9-14(17(13)24)10-1-3-11(23)4-2-10/h1-7,9,16,18-23,25-27H,8H2/t16-,18-,19+,20-,21-/m1/s1
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| InChIKey |
KYQZWONCHDNPDP-QNDFHXLGSA-N
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| CAS Number |
CAS 552-66-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:42202
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides J-37
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[1] | |||
| Hierarchy | ||||
| Resulting Metabolite | Daidzein; 2,4-dihydroxyacetophenone; 4-hydroxybenzoic acid; resorcinol; 4-hydroxyphenylacetic acid; 2,4-dihydroxybenzoic acid | |||
| Description | Daidzin can be metabolized to Daidzein, 2,4-dihydroxyacetophenone, 4-hydroxybenzoic acid, resorcinol, 4-hydroxyphenylacetic acid and 2,4-dihydroxybenzoic acid by Bacteroides J-37. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium sp.
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|
[2] | |||
| Hierarchy | ||||
| Metabolic Reaction | Glycosidic cleavage and reduction | |||
| Resulting Metabolite | Equol | |||
| Description | Daidzin can be metabolized to Equol by Bifidobacterium sp. through glycosidic cleavage and reduction. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella sp.
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|
[2] | |||
| Hierarchy | ||||
| Metabolic Reaction | Glycosidic cleavage and reduction | |||
| Resulting Metabolite | Equol | |||
| Description | Daidzin can be metabolized to Equol by Eggerthella sp. through glycosidic cleavage and reduction. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Eubacterium sp. A-44
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|
[1] | |||
| Hierarchy | ||||
| Resulting Metabolite | Daidzein; 2,4-dihydroxyacetophenone; 4-hydroxybenzoic acid; resorcinol; 4-hydroxyphenylacetic acid; 2,4-dihydroxybenzoic acid | |||
| Description | Daidzin can be metabolized to Daidzein, 2,4-dihydroxyacetophenone, 4-hydroxybenzoic acid, resorcinol, 4-hydroxyphenylacetic acid and 2,4-dihydroxybenzoic acid by Eubacterium sp. A-44. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Fusobacteriales | ||||
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Studied Microbe: Fusobacterium K-60
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|
[1] | |||
| Hierarchy | ||||
| Resulting Metabolite | Daidzein; 2,4-dihydroxyacetophenone; 4-hydroxybenzoic acid; resorcinol; 4-hydroxyphenylacetic acid; 2,4-dihydroxybenzoic acid | |||
| Description | Daidzin can be metabolized to Daidzein, 2,4-dihydroxyacetophenone, 4-hydroxybenzoic acid, resorcinol, 4-hydroxyphenylacetic acid and 2,4-dihydroxybenzoic acid by Fusobacterium K-60. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus faecium
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|
[2] | |||
| Hierarchy | ||||
| Metabolic Reaction | Glycosidic cleavage and reduction | |||
| Resulting Metabolite | Equol | |||
| Description | Daidzin can be metabolized to Equol by Enterococcus faecium through glycosidic cleavage and reduction. | |||
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Studied Microbe: Lactobacillus mucosae
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|
[2] | |||
| Hierarchy | ||||
| Metabolic Reaction | Glycosidic cleavage and reduction | |||
| Resulting Metabolite | Equol | |||
| Description | Daidzin can be metabolized to Equol by Lactobacillus mucosae through glycosidic cleavage and reduction. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [3], [4] | |||
| Metabolic Reaction | Deglycosylation, hydroxylation and methylation | |||
| Resulting Metabolite | Daidzein; calycosin | |||
| Metabolic Effect | Increase activity | |||
| Description | Daidzin can be metabolized to Daidzein and calycosin by gut microbiota through deglycosylation, hydroxylation and methylation, which results in the increase of the drug's activity. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Gut microbiota, a new frontier to understand traditional Chinese medicines. Pharmacol Res. 2019 Apr;142:176-191. | |||
| REF 2 | The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism. Nat Rev Microbiol. 2016 Apr;14(5):273-87. | |||
| REF 3 | Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity. Biol Pharm Bull. 1998 Jun;21(6):628-30. | |||
| REF 4 | Gut Microbiota-Mediated Drug-Antibiotic Interactions. Drug Metab Dispos. 2015 Oct;43(10):1581-9. | |||
| REF 5 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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