Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01VAB
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| Former ID |
DAP000941
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| Drug Name |
Alprenolol
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| Synonyms |
Alfeprol; Alpheprol; Alprenololum; Yobir; Alfeprol [Russian]; Alprenolol (INN); Alprenolol [INN:BAN]; Alprenololum [INN-Latin]; Apllobal (TN); Aptine (TN); Aptol (TN); Duriles (TN); Gubernal (TN); Regletin (TN); Yobir (TN); H-56-28; 1-(2-Allylphenoxy)-3-isopropylamino-2-propanol; 1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol; 1-(o-Allylphenoxy)-3-isopropylamino)-2-propanol; 1-(propan-2-ylamino)-3-(2-prop-2-enylphenoxy)propan-2-ol; 1-[2-(propen-2-ylphenoxy)]-3-(isopropylamino)propan-2-ol
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Withdrawn from market | [1], [2] | |
| Therapeutic Class |
Antiarrhythmic Agents
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| Company |
AstraZeneca
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H23NO2
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| Canonical SMILES |
CC(C)NCC(COC1=CC=CC=C1CC=C)O
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| InChI |
1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3
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| InChIKey |
PAZJSJFMUHDSTF-UHFFFAOYSA-N
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| CAS Number |
CAS 13655-52-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7403854, 8151437, 10507180, 11335190, 11360429, 11363062, 11365624, 11368186, 11371971, 11374790, 11376348, 11461401, 11466278, 11467398, 11485563, 11485995, 11489630, 11490881, 11493030, 11493982, 11534311, 15044941, 26752306, 29221299, 46506033, 47290959, 47440065, 47736281, 47810579, 47810580, 47885235, 48034925, 48034926, 48184817, 49698847, 50022618, 50105225, 50105226, 51091495, 56413052, 57321152, 80044758, 85209662, 85788463, 90340777, 92308802, 96099927, 103164453, 103852444, 104171111
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| ChEBI ID |
CHEBI:51211
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| SuperDrug ATC ID |
C07AA01
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| SuperDrug CAS ID |
cas=013655522
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
Show/Hide Hierarchy
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Alprenolol can be metabolized by Bifidobacterium ruminantium (log2FC = -0.339; p = 0.007). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-1 (ADRB1) | Target Info | Antagonist | [4], [5] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Gap junction | ||||
| Salivary secretion | ||||
| Dilated cardiomyopathy | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta1 adrenergic receptor signaling pathway | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Endothelin Pathways | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 563). | |||
| REF 2 | Drug information of Alprenolol, 2008. eduDrugs. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14555-60. | |||
| REF 5 | Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium. Br J Pharmacol. 1999 Jun;127(4):895-902. | |||
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