Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01USH
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| Former ID |
DIB018698
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| Drug Name |
7-hydroxycholesterol
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| Synonyms |
7-hydroxy-cholesterol; 7-OHC; SCHEMBL281943; GTPL3432; KB-200035
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C27H46O2
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| Canonical SMILES |
CC(C)CCCC(C)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C
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| InChI |
1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24?,25+,26+,27-/m1/s1
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| InChIKey |
OYXZMSRRJOYLLO-UOQFGJKXSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nuclear receptor ROR-alpha (RORA) | Target Info | Agonist | [2] |
| KEGG Pathway | Circadian rhythm | |||
| Inflammatory bowel disease (IBD) | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Reactome | RORA activates gene expression | |||
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
| PPARA activates gene expression | ||||
| Nuclear Receptor transcription pathway | ||||
| Circadian Clock | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Adipogenesis | ||||
| Circadian Clock | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3432). | |||
| REF 2 | Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach. Anal Biochem. 2003 Dec 1;323(1):139-49. | |||
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