Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01TNW
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| Former ID |
DCL000101
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| Drug Name |
Dapagliflozin
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| Synonyms |
BMS 512148; BMS-512148; BMS-512148, Dapagliflozin; Dapagliflozin (INN/USAN); 2-(3-(4-Ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol
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| Drug Type |
Small molecular drug
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| Indication | Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] | Approved | [1], [2], [3] | |
| Company |
AstraZeneca
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| Structure |
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Download2D MOL |
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| Formula |
C21H25ClO6
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| Canonical SMILES |
CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl
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| InChI |
1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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| InChIKey |
JVHXJTBJCFBINQ-ADAARDCZSA-N
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| CAS Number |
CAS 461432-26-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14855234, 15451267, 24173975, 45634651, 49688954, 57304407, 57373691, 76500746, 96025580, 103578280, 104253204, 109692963, 123051086, 124757330, 124772065, 125164134, 126667088, 126731318, 134338792, 134358357, 136348250, 136367545, 136367974, 137261282, 140046947, 143499356, 144115882, 152234916, 152258220, 160647056, 162011553, 162037657, 162172238, 164838825, 165245557, 170497930, 174529446, 175427068, 178101315, 185978787, 194946819, 198934677, 198991956, 210024059, 211535346, 221678783, 223471387, 223554897, 223670709, 223701082
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| ChEBI ID |
CHEBI:85078
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| ADReCS Drug ID | BADD_D00578 | |||
| SuperDrug ATC ID |
A10BX09
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium/glucose cotransporter 2 (SGLT2) | Target Info | Modulator | [2], [4] |
| Reactome | Hexose transport | |||
| Na+-dependent glucose transporters | ||||
| Inositol transporters | ||||
| WikiPathways | NRF2 pathway | |||
| Nuclear Receptors Meta-Pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4594). | |||
| REF 2 | 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 4 | Canagliflozin-current status in the treatment of type 2 diabetes mellitus with focus on clinical trial data.World J Diabetes.2014 Jun 15;5(3):399-406. | |||
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