Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01TDC
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| Former ID |
DNC013705
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| Drug Name |
6-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
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| Synonyms |
2-amino-5,6-dihydro-6-methyl-4h-1,3-thiazine; 1121-91-1; 6-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine; (+/-)-AMT hydrochloride; 4H-1,3-Thiazin-2-amine, 5,6-dihydro-6-methyl-; AC1L1BOF; Lopac0_000085; SCHEMBL523755; CHEMBL106322; CHEBI:91610; MolPort-009-018-788; BATVOUKHGLKDGQ-UHFFFAOYSA-N; FCH842002; AKOS006274541; CCG-204180; NCGC00024834-02; NCGC00015114-03; NCGC00015114-04; KB-19997; 5,6-dihydro-6-methyl-4h-1,3-thiazin-2-amine; C-41564
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C5H10N2S
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| Canonical SMILES |
CC1CCN=C(S1)N
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| InChI |
1S/C5H10N2S/c1-4-2-3-7-5(6)8-4/h4H,2-3H2,1H3,(H2,6,7)
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| InChIKey |
BATVOUKHGLKDGQ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:91610
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nitric-oxide synthase inducible (NOS2) | Target Info | Inhibitor | [1] |
| BioCyc | Citrulline-nitric oxide cycle | |||
| KEGG Pathway | Arginine biosynthesis | |||
| Arginine and proline metabolism | ||||
| Metabolic pathways | ||||
| Calcium signaling pathway | ||||
| HIF-1 signaling pathway | ||||
| Peroxisome | ||||
| Salmonella infection | ||||
| Pertussis | ||||
| Leishmaniasis | ||||
| Chagas disease (American trypanosomiasis) | ||||
| Toxoplasmosis | ||||
| Amoebiasis | ||||
| Tuberculosis | ||||
| Pathways in cancer | ||||
| Small cell lung cancer | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| Pathway Interaction Database | IL12-mediated signaling events | |||
| Alpha9 beta1 integrin signaling events | ||||
| ATF-2 transcription factor network | ||||
| IL23-mediated signaling events | ||||
| Signaling mediated by p38-alpha and p38-beta | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | ROS production in response to bacteria | |||
| Nitric oxide stimulates guanylate cyclase | ||||
| WikiPathways | Type II interferon signaling (IFNG) | |||
| Spinal Cord Injury | ||||
| AGE/RAGE pathway | ||||
| Effects of Nitric Oxide | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase. Bioorg Med Chem Lett. 2009 Jan 1;19(1):74-6. | |||
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