Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01SLS
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| Former ID |
DIB020381
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| Drug Name |
ML9
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| Synonyms |
ML-9 free base; UNII-LTJ3F5128V; 110448-31-2; LTJ3F5128V; CHEMBL429298; ML9; 1-[(5-chloro-1-naphthyl)sulfonyl]-1,4-diazepane; 1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-; Tocris-0431; ACMC-20mde5; BiomolKI_000043; AC1L1HOD; Lopac-C-1172; BiomolKI2_000008; Lopac0_000209; BSPBio_001271; GTPL4256; SCHEMBL2869228; CTK0D4761; CHEBI:93202; DTXSID00149246; ZINC402771; HMS1792O13; Bio1_000938; Bio1_001427; Bio1_000449; HMS3403O13; HMS1990O13; BDBM50216681; 1H-1,4-Diazepine, 1-((5-chloro-1-naphthalenyl)sulfonyl)hexahydro-)
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C15H17ClN2O2S
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| Canonical SMILES |
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3Cl
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| InChI |
1S/C15H17ClN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
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| InChIKey |
OZSMSRIUUDGTEP-UHFFFAOYSA-N
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| CAS Number |
CAS 110448-31-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
645243, 5184028, 8152637, 11110916, 11113497, 11120329, 11120817, 11121305, 14899534, 26751717, 26751718, 29223322, 47364973, 47662063, 47810538, 48184785, 50070800, 50104406, 50104407, 50290257, 85787784, 85789458, 90340625, 92310162, 99301074, 103550738, 104091017, 104305770, 124658742, 124879575, 124879576, 124879577, 124879578, 124879579, 128884852, 142880473, 162365302, 162439016, 163641279, 178101073, 179148695, 198967126, 223531050, 228939594, 252455886
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| ChEBI ID |
CHEBI:93202
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Short transient receptor potential channel 6 (TRPC6) | Target Info | Blocker (channel blocker) | [2] |
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Pathway Interaction Database | Endothelins | |||
| Nephrin/Neph1 signaling in the kidney podocyte | ||||
| EPO signaling pathway | ||||
| PAR1-mediated thrombin signaling events | ||||
| Reactome | Effects of PIP2 hydrolysis | |||
| TRP channels | ||||
| Role of second messengers in netrin-1 signaling | ||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | |||
| Platelet homeostasis | ||||
| Netrin-1 signaling | ||||
| GPCR downstream signaling | ||||
| Effects of PIP2 hydrolysis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4256). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). | |||
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