Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01RLU
|
|||
| Former ID |
DIB001964
|
|||
| Drug Name |
EG-016
|
|||
| Indication | Peripheral vascular disease [ICD-11: BD4Z; ICD-10: I73.9; ICD-9: 443.9] | Discontinued in Phase 1/2 | [1] | |
| Company |
Ark Therapeutics Group plc
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Vascular endothelial growth factor D (VEGFD) | Target Info | Modulator | [2] |
| KEGG Pathway | Ras signaling pathway | |||
| Rap1 signaling pathway | ||||
| Cytokine-cytokine receptor interaction | ||||
| PI3K-Akt signaling pathway | ||||
| Focal adhesion | ||||
| Pathways in cancer | ||||
| Pathway Interaction Database | Alpha9 beta1 integrin signaling events | |||
| VEGF and VEGFR signaling network | ||||
| VEGFR3 signaling in lymphatic endothelium | ||||
| Reactome | Platelet degranulation | |||
| VEGF ligand-receptor interactions | ||||
| VEGF binds to VEGFR leading to receptor dimerization | ||||
| WikiPathways | Focal Adhesion | |||
| Signaling by VEGF | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031989) | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030807) | |||
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