Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01OHV
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| Former ID |
DNC002551
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| Drug Name |
8-Azaguanine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C4H4N6O
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| Canonical SMILES |
C12=NNN=C1N=C(NC2=O)N
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| InChI |
1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
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| InChIKey |
LPXQRXLUHJKZIE-UHFFFAOYSA-N
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| CAS Number |
CAS 134-58-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
538242, 567032, 585500, 610608, 3139807, 3232652, 5092340, 5663736, 6481530, 6844808, 7886025, 8136887, 10321141, 10506957, 11112293, 11445991, 11446714, 11466029, 11467149, 11485658, 14992211, 17145076, 24847157, 24890963, 25634173, 29179181, 29227313, 39910158, 46505914, 47193666, 47220992, 47327226, 47495556, 47666545, 47666546, 47815008, 48189283, 49698301, 50057743, 57288351, 57325151, 57389457, 74440041, 85083973, 87225391, 87562197, 89090032, 90452290, 92124967, 92473935
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| ChEBI ID |
CHEBI:63486
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Bacteroides caccae
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Azaguanine-8 (adjusted p-values: 5.59E-03). | |||
|
Studied Microbe: Bacteroides fragilis enterotoxigenic
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Azaguanine-8 (adjusted p-values: 2.94E-05). | |||
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Studied Microbe: Bacteroides ovatus
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Azaguanine-8 (adjusted p-values: 4.49E-05). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Azaguanine-8 (adjusted p-values: 6.76E-05). | |||
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Studied Microbe: Bacteroides vulgatus
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Azaguanine-8 (adjusted p-values: 7.62E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Azaguanine-8 (adjusted p-values: 8.84E-05). | |||
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Studied Microbe: Clostridioides difficile
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Azaguanine-8 (adjusted p-values: 4.65E-03). | |||
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Studied Microbe: Coprococcus comes
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Azaguanine-8 (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Dorea formicigenerans
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Azaguanine-8 (adjusted p-values: 1.12E-03). | |||
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Studied Microbe: Enterocloster bolteae
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Azaguanine-8 (adjusted p-values: 5.17E-04). | |||
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Studied Microbe: Eubacterium rectale
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Azaguanine-8 (adjusted p-values: 1.96E-04). | |||
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Studied Microbe: Lacrimispora saccharolytica
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Azaguanine-8 (adjusted p-values: 1.66E-06). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
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