Drug Information
Drug General Information | Top | |||
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Drug ID |
D01OGZ
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Former ID |
DNC011951
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Drug Name |
TEFLUDAZINE
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Synonyms |
Tefludazine; Tefludazine [INN]; Tefludazinum [Latin]; Tefludazina [Spanish]; Lu 18-012; CHEMBL95636; trans-4-[3-(p-fluorophenyl)-6-(trifluoromethyl)-1-indanyl]-1-piperazineethanol; 2-(4-(trans-3-(4-Fluorphenyl-6-trifluormethyl-1-indanyl)-1-piperazinyl)ethanol; 80273-79-6; Tefludazinum; Tefludazina; trans-4-(3-(p-Fluorophenyl)-6-(trifluoromethyl)-1-indanyl)-1-piperazineethanol; 1-Piperazineethanol, 4-(3-(4-fluorophenyl)-2,3-dihydro-6-(trifluoromethyl)-1H-indel-1-yl)-, trans-(+-)-; (1R,3S)-Tefludazine; AC1L2FT8; AC1Q4JR0
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C22H24F4N2O
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Canonical SMILES |
C1CN(CCN1CCO)C2CC(C3=C2C=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)F
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InChI |
1S/C22H24F4N2O/c23-17-4-1-15(2-5-17)19-14-21(28-9-7-27(8-10-28)11-12-29)20-13-16(22(24,25)26)3-6-18(19)20/h1-6,13,19,21,29H,7-12,14H2/t19-,21+/m0/s1
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InChIKey |
JSBWGXQXCRYYTG-PZJWPPBQSA-N
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CAS Number |
CAS 80273-79-6
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Serotonin transporter (SERT) | Target Info | Inhibitor | [1] |
KEGG Pathway | Serotonergic synapse | |||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
5HT2 type receptor mediated signaling pathway | ||||
5HT3 type receptor mediated signaling pathway | ||||
5HT4 type receptor mediated signaling pathway | ||||
WikiPathways | Monoamine Transport | |||
SIDS Susceptibility Pathways | ||||
NRF2 pathway | ||||
Synaptic Vesicle Pathway | ||||
Serotonin Transporter Activity |
References | Top | |||
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REF 1 | Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans. J Med Chem. 1983 Jul;26(7):935-47. |
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