Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01OFY
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| Former ID |
DIB008040
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| Drug Name |
LAS-31180
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| Synonyms |
LAS-31180; LAS 31180; 137338-43-3; AC1Q6VQ1; AC1L50OY; ZINC8845; SCHEMBL7287896; DTXSID70160140; n-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)methanesulfonamide; CS-6714; HY-101811
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| Drug Type |
Small molecular drug
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| Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Terminated | [1] | |
| Company |
Almirall Prodesfarma SA
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H12N2O3S
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| Canonical SMILES |
CN1C=C(C(=O)C2=CC=CC=C21)NS(=O)(=O)C
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| InChI |
1S/C11H12N2O3S/c1-13-7-9(12-17(2,15)16)11(14)8-5-3-4-6-10(8)13/h3-7,12H,1-2H3
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| InChIKey |
LSIYNVMXGMDGMG-UHFFFAOYSA-N
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| CAS Number |
CAS 137338-43-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 3A (PDE3A) | Target Info | Modulator | [1] |
| KEGG Pathway | Purine metabolism | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | cGMP effects | |||
| G alpha (s) signalling events | ||||
| WikiPathways | miR-targeted genes in muscle cell - TarBase | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6. | |||
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