Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01NJE
|
|||
| Former ID |
DNC001612
|
|||
| Drug Name |
ED45
|
|||
| Drug Type |
Aptamer
|
|||
| Indication | Acute respiratory distress syndrome [ICD-11: CB00; ICD-10: J80] | Investigative | [1] | |
| Myocardial reperfusion injury [ICD-11: NB31] | Investigative | [1] | ||
| Sepsis [ICD-11: 1G40-1G41] | Investigative | [1] | ||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neutrophil elastase (NE) | Target Info | . | [1] |
| KEGG Pathway | Transcriptional misregulation in cancer | |||
| Systemic lupus erythematosus | ||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
| C-MYB transcription factor network | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
| Human Complement System | ||||
| Degradation of collagen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. | |||
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