| Target and Pathway |
Top |
| Target(s) |
PI3-kinase alpha (PIK3CA) |
Target Info
|
Inhibitor |
[1] |
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BioCyc
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Superpathway of inositol phosphate compounds
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3-phosphoinositide biosynthesis
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KEGG Pathway
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Inositol phosphate metabolism
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ErbB signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
|
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cGMP-PKG signaling pathway
|
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cAMP signaling pathway
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Chemokine signaling pathway
|
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HIF-1 signaling pathway
|
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FoxO signaling pathway
|
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Phosphatidylinositol signaling system
|
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Sphingolipid signaling pathway
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mTOR signaling pathway
|
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PI3K-Akt signaling pathway
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AMPK signaling pathway
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Apoptosis
|
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Adrenergic signaling in cardiomyocytes
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VEGF signaling pathway
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Osteoclast differentiation
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Focal adhesion
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Signaling pathways regulating pluripotency of stem cells
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Platelet activation
|
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Toll-like receptor signaling pathway
|
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Jak-STAT signaling pathway
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Natural killer cell mediated cytotoxicity
|
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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Fc gamma R-mediated phagocytosis
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TNF signaling pathway
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Leukocyte transendothelial migration
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Neurotrophin signaling pathway
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Cholinergic synapse
|
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Inflammatory mediator regulation of TRP channels
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Regulation of actin cytoskeleton
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Insulin signaling pathway
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Progesterone-mediated oocyte maturation
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Estrogen signaling pathway
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Regulation of lipolysis in adipocytes
|
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Type II diabetes mellitus
|
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Non-alcoholic fatty liver disease (NAFLD)
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Aldosterone-regulated sodium reabsorption
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Carbohydrate digestion and absorption
|
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Bacterial invasion of epithelial cells
|
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Amoebiasis
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Hepatitis C
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Hepatitis B
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Measles
|
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Influenza A
|
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HTLV-I infection
|
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Epstein-Barr virus infection
|
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Pathways in cancer
|
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Viral carcinogenesis
|
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Proteoglycans in cancer
|
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MicroRNAs in cancer
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Colorectal cancer
|
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Renal cell carcinoma
|
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Pancreatic cancer
|
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Endometrial cancer
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Glioma
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Prostate cancer
|
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Melanoma
|
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Chronic myeloid leukemia
|
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Acute myeloid leukemia
|
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Small cell lung cancer
|
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Non-small cell lung cancer
|
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Central carbon metabolism in cancer
|
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Choline metabolism in cancer
|
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Panther Pathway
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Angiogenesis
|
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Apoptosis signaling pathway
|
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Axon guidance mediated by netrin
|
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B cell activation
|
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
|
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Hypoxia response via HIF activation
|
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Inflammation mediated by chemokine and cytokine signaling pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
|
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Integrin signalling pathway
|
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Interleukin signaling pathway
|
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PDGF signaling pathway
|
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PI3 kinase pathway
|
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T cell activation
|
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VEGF signaling pathway
|
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p53 pathway
|
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Ras Pathway
|
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p53 pathway feedback loops 2
|
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Pathwhiz Pathway
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Inositol Metabolism
|
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Phosphatidylinositol Phosphate Metabolism
|
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
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Pathway Interaction Database
|
Fc-epsilon receptor I signaling in mast cells
|
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BCR signaling pathway
|
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ErbB4 signaling events
|
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Insulin Pathway
|
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GMCSF-mediated signaling events
|
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Atypical NF-kappaB pathway
|
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IL4-mediated signaling events
|
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Plasma membrane estrogen receptor signaling
|
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Signaling events mediated by PTP1B
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EPHB forward signaling
|
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Osteopontin-mediated events
|
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Reelin signaling pathway
|
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Nectin adhesion pathway
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TRAIL signaling pathway
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CDC42 signaling events
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Signaling events regulated by Ret tyrosine kinase
|
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Signaling events mediated by TCPTP
|
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Angiopoietin receptor Tie2-mediated signaling
|
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FAS (CD95) signaling pathway
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SHP2 signaling
|
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Netrin-mediated signaling events
|
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IL1-mediated signaling events
|
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IL2-mediated signaling events
|
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CXCR4-mediated signaling events
|
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IGF1 pathway
|
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EGF receptor (ErbB1) signaling pathway
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IL5-mediated signaling events
|
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Class I PI3K signaling events
|
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IL2 signaling events mediated by PI3K
|
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p75(NTR)-mediated signaling
|
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E-cadherin signaling in the nascent adherens junction
|
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Integrins in angiogenesis
|
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IFN-gamma pathway
|
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ErbB1 downstream signaling
|
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ErbB2/ErbB3 signaling events
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IL3-mediated signaling events
|
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IL6-mediated signaling events
|
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E-cadherin signaling in keratinocytes
|
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PDGFR-beta signaling pathway
|
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Neurotrophic factor-mediated Trk receptor signaling
|
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Nephrin/Neph1 signaling in the kidney podocyte
|
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IL23-mediated signaling events
|
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PDGFR-alpha signaling pathway
|
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Signaling events mediated by the Hedgehog family
|
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Nongenotropic Androgen signaling
|
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Internalization of ErbB1
|
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CXCR3-mediated signaling events
|
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VEGFR1 specific signals
|
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Signaling events mediated by Stem cell factor receptor (c-Kit)
|
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IL2 signaling events mediated by STAT5
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
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PAR1-mediated thrombin signaling events
|
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a6b1 and a6b4 Integrin signaling
|
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Ephrin B reverse signaling
|
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N-cadherin signaling events
|
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Trk receptor signaling mediated by PI3K and PLC-gamma
|
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EPHA2 forward signaling
|
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VEGFR3 signaling in lymphatic endothelium
|
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FGF signaling pathway
|
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Signaling events mediated by focal adhesion kinase
|
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Reactome
|
PI3K Cascade
|
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GPVI-mediated activation cascade
|
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Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
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PI3K events in ERBB4 signaling
|
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PIP3 activates AKT signaling
|
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GAB1 signalosome
|
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PI3K events in ERBB2 signaling
|
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PI3K/AKT activation
|
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Role of phospholipids in phagocytosis
|
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Tie2 Signaling
|
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Constitutive Signaling by Aberrant PI3K in Cancer
|
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DAP12 signaling
|
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Role of LAT2/NTAL/LAB on calcium mobilization
|
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Nephrin interactions
|
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Costimulation by the CD28 family
|
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CD28 dependent PI3K/Akt signaling
|
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G beta:gamma signalling through PI3Kgamma
|
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G alpha (q) signalling events
|
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G alpha (12/13) signalling events
|
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VEGFA-VEGFR2 Pathway
|
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Interleukin-3, 5 and GM-CSF signaling
|
|
Constitutive Signaling by EGFRvIII
|
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PI-3K cascade:FGFR1
|
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PI-3K cascade:FGFR2
|
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PI-3K cascade:FGFR3
|
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PI-3K cascade:FGFR4
|
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Interleukin receptor SHC signaling
|
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Regulation of signaling by CBL
|
|
WikiPathways
|
Toll-like receptor signaling pathway
|
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Serotonin HTR1 Group and FOS Pathway
|
|
DNA Damage Response (only ATM dependent)
|
|
G13 Signaling Pathway
|
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Regulation of Actin Cytoskeleton
|
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Insulin Signaling
|
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IL-4 Signaling Pathway
|
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Signaling of Hepatocyte Growth Factor Receptor
|
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Transcriptional activation by NRF2
|
|
IL1 and megakaryotyces in obesity
|
|
Signaling by ERBB4
|
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Signaling by ERBB2
|
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Fc epsilon receptor (FCERI) signaling
|
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PI Metabolism
|
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Interleukin-2 signaling
|
|
Fcgamma receptor (FCGR) dependent phagocytosis
|
|
Signaling by SCF-KIT
|
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DAP12 interactions
|
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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
|
PIP3 activates AKT signaling
|
|
Integrated Pancreatic Cancer Pathway
|
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Prostate Cancer
|
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Signaling Pathways in Glioblastoma
|
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TSLP Signaling Pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
TSH signaling pathway
|
|
SREBP signalling
|
|
TCR signaling
|
|
Signaling by PDGF
|
|
Signaling by Insulin receptor
|
|
Signaling by FGFR
|
|
Signaling by EGFR
|
|
NGF signalling via TRKA from the plasma membrane
|
|
Nephrin interactions
|
|
Interleukin-3, 5 and GM-CSF signaling
|
|
GPVI-mediated activation cascade
|
|
GPCR downstream signaling
|
|
Costimulation by the CD28 family
|
|
Cell surface interactions at the vascular wall
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
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Angiogenesis
|
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Regulation of toll-like receptor signaling pathway
|
|
AMPK Signaling
|
