Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01JFT
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| Former ID |
DAP000593
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| Drug Name |
Dipivefrin
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| Synonyms |
AKPro; Dipivefrina; Dipivefrine; Dipivefrinum; Propine; Dipivalyl epinephrine; Dipivefrin HCL; Dipivefrin [USAN]; K 30081; Dipivefrin (USAN); Dipivefrina [INN-Spanish]; Dipivefrine (INN); Dipivefrinum [INN-Latin]; Ophtho-Dipivefrin; Propine C Cap B.I.D.; [2-(2,2-dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate; (+-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol 3,4-dipivalate; (+-)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate; (-)-2,2-Dimethylpropansaeure-4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylenester; (-)-4-(1-Hydroxy-2-methylaminoethyl)-o-phenylendipivalat; (RS)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat; 1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol; 2,2-Dimethylpropanoic acid 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat; 4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate; 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diyl bis(2,2-dimethylpropanoate)
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| Drug Type |
Small molecular drug
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| Indication | Chronic open-angle glaucoma [ICD-11: 9C61.0; ICD-10: H40.1] | Approved | [1] | |
| Therapeutic Class |
Ophthalmologicals
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| Company |
Allergan Pharmaceutical
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H29NO5
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| Canonical SMILES |
CC(C)(C)C(=O)OC1=C(C=C(C=C1)C(CNC)O)OC(=O)C(C)(C)C
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| InChI |
1S/C19H29NO5/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6/h8-10,13,20-21H,11H2,1-7H3
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| InChIKey |
OCUJLLGVOUDECM-UHFFFAOYSA-N
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| CAS Number |
CAS 52365-63-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9177, 5046070, 7849408, 7849627, 7979105, 8151976, 11466660, 11467780, 11486579, 14900877, 29222248, 46504716, 47730764, 47805070, 47953978, 48253458, 49699363, 50022390, 50124214, 57321612, 76534349, 85209619, 85787969, 99319096, 104302537, 108209497, 124974073, 126686842, 128790429, 134223686, 134337884, 135001947, 137125825, 142059953, 143311428, 160963795, 178103741, 179150547, 184547693, 221672763, 223672453, 226412985, 241092031, 250133605, 251912307, 251916618, 252348563
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| ChEBI ID |
CHEBI:4646
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| ADReCS Drug ID | BADD_D00689 ; BADD_D00690 | |||
| SuperDrug ATC ID |
S01EA02
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| SuperDrug CAS ID |
cas=052365636
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-1 (ADRB1) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Gap junction | ||||
| Salivary secretion | ||||
| Dilated cardiomyopathy | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta1 adrenergic receptor signaling pathway | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Endothelin Pathways | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Contractile response of the isolated trabecular meshwork and ciliary muscle to cholinergic and adrenergic agents. Ger J Ophthalmol. 1996 May;5(3):146-53. | |||
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