Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01GQD
|
|||
| Former ID |
DCL001183
|
|||
| Drug Name |
EZN-3042
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
| Company |
Santaris Pharma A/S
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Apoptosis inhibitor survivin (BIRC5) | Target Info | Modulator | [2] |
| KEGG Pathway | Hippo signaling pathway | |||
| Hepatitis B | ||||
| Pathways in cancer | ||||
| Colorectal cancer | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Angiogenesis | |||
| Pathway Interaction Database | Aurora B signaling | |||
| Validated targets of C-MYC transcriptional activation | ||||
| FOXM1 transcription factor network | ||||
| Aurora A signaling | ||||
| Reactome | Separation of Sister Chromatids | |||
| Resolution of Sister Chromatid Cohesion | ||||
| RHO GTPases Activate Formins | ||||
| Mitotic Prometaphase | ||||
| WikiPathways | IL-4 Signaling Pathway | |||
| Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
| Mitotic Metaphase and Anaphase | ||||
| Mitotic Prometaphase | ||||
| Apoptosis | ||||
| Interleukin-11 Signaling Pathway | ||||
| Apoptosis Modulation and Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2011 Pipeline of Santaris Pharma. | |||
| REF 2 | SPC3042: a proapoptotic survivin inhibitor.Mol Cancer Ther.2008 Sep;7(9):2736-45. | |||
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