Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01GEO
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| Former ID |
DNC001422
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| Drug Name |
Telomestatin
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| Synonyms |
YVSQVYZBDXIXCC-UHFFFAOYSA-N; AC1L9EVW; CHEMBL443683; CHEBI:29689; Telomestatin (TMS); gm95; SureCN10025441; SCHEMBL10025441; CHEBI:601758; BDBM213233; DCL000983
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| Drug Type |
Small molecular drug
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| Indication | Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0] | Investigative | [1] | |
| Company |
Geron Corp
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| Structure |
 |
Download2D MOL |
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| Formula |
C26H14N8O7S
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| Canonical SMILES |
CC1=C2C3=NC(=C(O3)C)C4=NC(=CO4)C5=NC(=CO5)C6=NC(=CO6)C7=NC(=CO7)C8=NC(=CO8)C9=NC(CS9)C(=N2)O1
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| InChI |
1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,16H,8H2,1-2H3
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| InChIKey |
YVSQVYZBDXIXCC-UHFFFAOYSA-N
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| CAS Number |
CAS 265114-54-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:29689
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Telomerase reverse transcriptase (TERT) | Target Info | Inhibitor | [1] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
| Regulation of Telomerase | ||||
| IL2 signaling events mediated by PI3K | ||||
| Regulation of nuclear beta catenin signaling and target gene transcription | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Formation of the beta-catenin:TCF transactivating complex | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. | |||
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