Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01FYA
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| Drug Name |
PU-H71
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| Synonyms |
PU-H71; 873436-91-0; PU H71; PU-H 71; UNII-06IVK87M04; CHEMBL200102; 06IVK87M04; 6-amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-n-(1-methylethyl)-9h-purine-9-propanamine; NSC 750424; 8-[(6-Iodo-1,3-Benzodioxol-5-Yl)thio]-9-[3-(Isopropylamino)propyl]-9h-Purin-6-Amine; 8-(6-Iodobenzo[d][1,3]dioxol-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine; 8-((6-Iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine; H71; PUH-71; 2fwz; PU-H-71
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Phase 1 | [1] | |
| Myelofibrosis [ICD-11: 2A20.2; ICD-10: D47.4] | Phase 1 | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [2] | ||
| Structure |
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Download2D MOL |
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| Formula |
C18H21IN6O2S
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| Canonical SMILES |
CC(C)NCCCN1C2=NC=NC(=C2N=C1SC3=C(C=C4C(=C3)OCO4)I)N
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| InChI |
1S/C18H21IN6O2S/c1-10(2)21-4-3-5-25-17-15(16(20)22-8-23-17)24-18(25)28-14-7-13-12(6-11(14)19)26-9-27-13/h6-8,10,21H,3-5,9H2,1-2H3,(H2,20,22,23)
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| InChIKey |
SUPVGFZUWFMATN-UHFFFAOYSA-N
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| CAS Number |
CAS 873436-91-0
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| PubChem Compound ID | ||||
| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Heat shock protein 90 beta (HSP90B) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Protein processing in endoplasmic reticulum | |||
| PI3K-Akt signaling pathway | ||||
| Necroptosis | ||||
| Antigen processing and presentation | ||||
| NOD-like receptor signaling pathway | ||||
| IL-17 signaling pathway | ||||
| Th17 cell differentiation | ||||
| Progesterone-mediated oocyte maturation | ||||
| Estrogen signaling pathway | ||||
| Pathways in cancer | ||||
| Prostate cancer | ||||
| Fluid shear stress and atherosclerosis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | |||
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