Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01EBY
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| Former ID |
DNC002429
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| Drug Name |
L-Thiocitrulline
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| Synonyms |
L-thiocitrulline; (S)-2-Amino-5-(thioureido)pentanoic acid; CHEMBL93247; SCI; (2S)-2-amino-5-[(aminothioxomethyl)amino]pentanoic acid; AC1MBZ2U; KBioGR_000498; BSPBio_001158; KBioSS_000498; SCHEMBL156220; KBio3_000915; KBio2_005634; KBio2_003066; KBio2_000498; KBio3_000916; Thio-L-citrulline, > BKGWACHYAMTLAF-BYPYZUCNSA-N; HMS3403J19; HMS1990J19; Bio1_000374; HMS1362J19; Bio2_000899; HMS1792J19; Bio2_000419; Bio1_001352; Bio1_000863
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C6H13N3O2S
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| Canonical SMILES |
C(CC(C(=O)O)N)CNC(=S)N
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| InChI |
1S/C6H13N3O2S/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1
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| InChIKey |
BKGWACHYAMTLAF-BYPYZUCNSA-N
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| CAS Number |
CAS 156719-37-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3153184, 7890409, 8029269, 8794639, 11120254, 11120742, 11121230, 11121764, 11122244, 11362912, 11365474, 11368036, 11371015, 11371016, 11373637, 11376198, 14748515, 15322270, 24889109, 26756870, 30091337, 46505566, 47364948, 47364949, 48498532, 49786879, 50111469, 57409559, 57653314, 78201535, 90341707, 92310115, 99301027, 99302547, 103305728, 103992948, 111358661, 124576994, 125235758, 127528001, 132520469, 135330108, 135372026, 135694784, 135696144, 137065252, 140341575, 143146272, 160967025, 162226223
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nitric-oxide synthase inducible (NOS2) | Target Info | Inhibitor | [1] |
| BioCyc | Citrulline-nitric oxide cycle | |||
| KEGG Pathway | Arginine biosynthesis | |||
| Arginine and proline metabolism | ||||
| Metabolic pathways | ||||
| Calcium signaling pathway | ||||
| HIF-1 signaling pathway | ||||
| Peroxisome | ||||
| Salmonella infection | ||||
| Pertussis | ||||
| Leishmaniasis | ||||
| Chagas disease (American trypanosomiasis) | ||||
| Toxoplasmosis | ||||
| Amoebiasis | ||||
| Tuberculosis | ||||
| Pathways in cancer | ||||
| Small cell lung cancer | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| Pathway Interaction Database | IL12-mediated signaling events | |||
| Alpha9 beta1 integrin signaling events | ||||
| ATF-2 transcription factor network | ||||
| IL23-mediated signaling events | ||||
| Signaling mediated by p38-alpha and p38-beta | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | ROS production in response to bacteria | |||
| Nitric oxide stimulates guanylate cyclase | ||||
| WikiPathways | Type II interferon signaling (IFNG) | |||
| Spinal Cord Injury | ||||
| AGE/RAGE pathway | ||||
| Effects of Nitric Oxide | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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