Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01DHT
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| Drug Name |
Azole derivative 7
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| Synonyms |
PMID25470667-Compound-Figure5-9
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| Drug Type |
Small molecular drug
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| Company |
MERCK SHARP &amDOHME CORP. DEVITA, Robert, J. HE, Shuwen LIU, Jian CERNAK, Timothy, A. KRIKORIAN, Arto, D. YANG, Ginger XuQiang WU, Zhicai YU, Yang SHEN, Dong-Ming LAI, Zhong HONG, Qingmei NARGUND, Ravi, P
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| Structure |
 |
Download2D MOL |
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| Formula |
C27H25FN4O2
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| Canonical SMILES |
C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)C3=NC=C(C=C3)C4=NNC(=N4)C5=CC(=CC=C5)F
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| InChI |
1S/C27H25FN4O2/c28-23-3-1-2-21(15-23)26-30-27(32-31-26)22-12-13-24(29-16-22)20-10-8-19(9-11-20)18-6-4-17(5-7-18)14-25(33)34/h1-3,8-13,15-18H,4-7,14H2,(H,33,34)(H,30,31,32)
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| InChIKey |
IMVHPASOWCDZEL-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Diacylglycerol acyltransferase 1 (DGAT1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Diacylglycerol acyltransferase 1 (DGAT1) | Target's Patent Info | [1] | |
| BioCyc | Triacylglycerol biosynthesis | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Retinol metabolism | ||||
| Metabolic pathways | ||||
| Fat digestion and absorption | ||||
| Pathwhiz Pathway | Retinol Metabolism | |||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Triglyceride Biosynthesis | ||||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Statin Pathway | ||||
| Triacylglyceride Synthesis | ||||
| Glycerophospholipid biosynthesis | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. | |||
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