Drug Information
Drug General Information | Top | |||
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Drug ID |
D01DAQ
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Former ID |
DNC010617
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Drug Name |
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil
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Synonyms |
CHEMBL1080896; 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C8H8FN5O2
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Canonical SMILES |
C1=CN(C(=N1)N)CC2=C(C(=O)NC(=O)N2)F
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InChI |
1S/C8H8FN5O2/c9-5-4(12-8(16)13-6(5)15)3-14-2-1-11-7(14)10/h1-2H,3H2,(H2,10,11)(H2,12,13,15,16)
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InChIKey |
SFEMKOUUPCFITA-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
KEGG Pathway | Pyrimidine metabolism | |||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Bladder cancer | ||||
NetPath Pathway | TSH Signaling Pathway | |||
Pathwhiz Pathway | Pyrimidine Metabolism | |||
WikiPathways | Bladder Cancer | |||
Metabolism of nucleotides | ||||
Fluoropyrimidine Activity |
References | Top | |||
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REF 1 | The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51. |
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