Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01CTM
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| Former ID |
DIB019357
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| Drug Name |
PMID21823616C22
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| Synonyms |
ILK-IN-1; OSU-T315; 1333146-24-9; GTPL8116; BCP23690; ZINC72120050; BDBM50353484; AKOS030257532; CS-4936; HY-18676; SC-98385
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL
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| Formula |
C30H30F3N5O
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| Canonical SMILES |
CNC(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)N5CCNCC5
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| InChI |
1S/C30H30F3N5O/c1-34-29(39)15-10-25-20-28(38(36-25)27-13-11-26(12-14-27)37-18-16-35-17-19-37)23-4-2-21(3-5-23)22-6-8-24(9-7-22)30(31,32)33/h2-9,11-14,20,35H,10,15-19H2,1H3,(H,34,39)
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| InChIKey |
GHBUPSVATJKTRR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Integrin-linked protein kinase 1 (ILK) | Target Info | Inhibitor | [2] |
| NetPath Pathway | TCR Signaling Pathway | |||
| FSH Signaling Pathway | ||||
| Panther Pathway | Integrin signalling pathway | |||
| Pathway Interaction Database | Osteopontin-mediated events | |||
| Integrin-linked kinase signaling | ||||
| Integrins in angiogenesis | ||||
| Reactome | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | |||
| WikiPathways | Eukaryotic Transcription Initiation | |||
| Focal Adhesion | ||||
| Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| Integrin-mediated Cell Adhesion | ||||
| Cell junction organization | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma. PLoS One. 2011 Feb 9;6(2):e16984. | |||
| REF 2 | Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 2011 Sep 22;54(18):6364-74. | |||
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