Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00YTQ
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| Former ID |
DNC000333
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| Drug Name |
BMS-345541
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| Synonyms |
445430-58-0; BMS345541; BMS-345541 free base; BMS-345541 (free base); UNII-26SU0NEF5F; N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine; 26SU0NEF5F; IKK Inhibitor III, BMS-345541; C14H17N5; 4-(2& -Aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline; BMS-345541(free base); IKK Inhibitor III; Kinome_3215; SCHEMBL118886; GTPL5669; CHEMBL249697; CTK8E9618; KS-00001CRN; CHEBI:91340; BDBM25919; DTXSID60196216; PSPFQEBFYXJZEV-UHFFFAOYSA-N; MolPort-035-395-836; HMS3653F06; HMS2043P05
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| Drug Type |
Small molecular drug
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| Indication | Arthritis [ICD-11: FA20] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C14H18ClN5
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| Canonical SMILES |
CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN.Cl
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| InChI |
1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H
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| InChIKey |
MIDKPVLYXNLFGZ-UHFFFAOYSA-N
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| CAS Number |
CAS 445430-59-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14770661, 24118760, 26758928, 29217517, 44849732, 46493744, 56413207, 57373403, 77469241, 92729728, 103551463, 103905281, 121270656, 135685135, 142629859, 163124530, 163620708, 163686025, 163687917, 171061165, 172650093, 172918695, 174006980, 177748862, 178102297, 179694521, 185969798, 198982142, 204378859, 223795966, 226088067, 226490737, 247171244, 252470825
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| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5669). | |||
| REF 2 | A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum. 2003 Sep;48(9):2652-9. | |||
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