Drug Information
Drug General Information | Top | |||
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Drug ID |
D00YGA
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Former ID |
DIB014466
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Drug Name |
SB-219994
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Synonyms |
SB-219993
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Drug Type |
Small molecular drug
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Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Terminated | [1], [2] | |
Company |
SmithKline Beecham plc
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Structure |
Download2D MOL |
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Formula |
C21H21F3N2O5
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Canonical SMILES |
CN(CCOC1=CC=C(C=C1)CC(C(=O)O)OCC(F)(F)F)C2=NC3=CC=CC=C3O2
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InChI |
1S/C21H21F3N2O5/c1-26(20-25-16-4-2-3-5-17(16)31-20)10-11-29-15-8-6-14(7-9-15)12-18(19(27)28)30-13-21(22,23)24/h2-9,18H,10-13H2,1H3,(H,27,28)/t18-/m0/s1
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InChIKey |
IRAAJHYKQDFNFO-SFHVURJKSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2698). | |||
REF 2 | Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma. J Pharmacol Exp Ther. 1998 Feb;284(2):751-9. | |||
REF 3 | PPAR-gamma agonists as therapy for diseases involving airway neutrophilia. Eur Respir J. 2004 Jul;24(1):18-23. |
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