Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00XRI
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| Former ID |
DIB014283
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| Drug Name |
TJN-220
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| Synonyms |
O-Ethylfangchinoline; O-ethylfangchinoline, Tsumura; 7-O-ethylfangchinoline, Tsumura
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1] | |
| Company |
Tsumura & Co
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| Structure |
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Download2D MOL |
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| Formula |
C39H44N2O6
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| Canonical SMILES |
CCOC1=C(C=C2CCN(C3C2=C1OC4=C(C=C5CCN(C(C5=C4)CC6=CC=C(C=C6)OC7=C(C=CC(=C7)C3)OC)C)OC)C)OC
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| InChI |
1S/C39H44N2O6/c1-7-45-38-36(44-6)22-27-15-17-41(3)31-19-25-10-13-32(42-4)34(20-25)46-28-11-8-24(9-12-28)18-30-29-23-35(47-39(38)37(27)31)33(43-5)21-26(29)14-16-40(30)2/h8-13,20-23,30-31H,7,14-19H2,1-6H3/t30-,31-/m0/s1
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| InChIKey |
VNBSKOLSTYLJBG-CONSDPRKSA-N
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| CAS Number |
CAS 118160-59-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcitonin receptor (CALCR) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Osteoclast differentiation | ||||
| NetPath Pathway | RANKL Signaling Pathway | |||
| Reactome | G alpha (s) signalling events | |||
| Calcitonin-like ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| RANKL/RANK Signaling Pathway | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002586) | |||
| REF 2 | Evaluation of the long-lasting antihypertensive action of 7-O-ethylfangchinoline. Jpn J Pharmacol. 1994 Sep;66(1):35-46. | |||
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