Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00XEU
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| Former ID |
DCL000124
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| Drug Name |
GSK-923295
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| Synonyms |
1088965-37-0; GSK-923295; GSK923295; 3-Chloro-N-((S)-1-(2-(dimethylamino)acetamido)-3-(4-(8-((S)-1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-4-isopropoxybenzamide; 3-Chloro-N-((S)-1-(2-(dimethylamino)acetamido)-3-(4-(8-((S)-1-hydroxyethyl)-imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-4-isopropoxybenzamide; GSK 923295; MLS006011170; SCHEMBL1492164; UNII-072702W9QD; CTK8C0600; DTXSID50677145; GSK-295; AOB5937; EX-A633; MolPort-023-332-816; GSK-923295A; BCP09858; ANW-64945; s7090; ZINC68151184; AKOS016005270
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Terminated | [1] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
GlaxoSmithKline
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| Structure |
 |
Download2D MOL |
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| Formula |
C32H38ClN5O4
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| Canonical SMILES |
CC(C)OC1=C(C=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)C3=CN4C=CC=C(C4=N3)C(C)O)CNC(=O)CN(C)C)Cl
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| InChI |
1S/C32H38ClN5O4/c1-20(2)42-29-13-12-24(16-27(29)33)32(41)35-25(17-34-30(40)19-37(4)5)15-22-8-10-23(11-9-22)28-18-38-14-6-7-26(21(3)39)31(38)36-28/h6-14,16,18,20-21,25,39H,15,17,19H2,1-5H3,(H,34,40)(H,35,41)/t21-,25-/m0/s1
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| InChIKey |
WHMXDBPHBVLYRC-OFVILXPXSA-N
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| CAS Number |
CAS 1088965-37-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Centromeric protein E (CENPE) | Target Info | Inhibitor | [2] |
| Pathway Interaction Database | PLK1 signaling events | |||
| Reactome | MHC class II antigen presentation | |||
| Separation of Sister Chromatids | ||||
| Resolution of Sister Chromatid Cohesion | ||||
| RHO GTPases Activate Formins | ||||
| Mitotic Prometaphase | ||||
| Kinesins | ||||
| WikiPathways | Mitotic Metaphase and Anaphase | |||
| MHC class II antigen presentation | ||||
| Mitotic Prometaphase | ||||
| Kinesins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026868) | |||
| REF 2 | Cytokinetics Announces Non-Clinical Trial Data Presented at 2007 AACR Annual Meeting. Cytokinetics, Incorporated. 2007. | |||
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