Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00WHL
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| Former ID |
DIB014990
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| Drug Name |
Juvidex
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| Synonyms |
Adaprev; Mannose-6-phosphate (scarring), Renovo
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| Indication | Sarcoidosis [ICD-11: 4B20.5; ICD-10: D86.3] | Phase 2 | [1] | |
| Company |
Renovo Group plc
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| Structure |
 |
Download2D MOL |
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| Formula |
C6H13O9P
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| Canonical SMILES |
C(C(C(C(C(C=O)O)O)O)O)OP(=O)(O)O
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| InChI |
1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h1,3-6,8-11H,2H2,(H2,12,13,14)/t3-,4-,5-,6-/m1/s1
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| InChIKey |
VFRROHXSMXFLSN-KVTDHHQDSA-N
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| CAS Number |
CAS 3672-15-9
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:48042
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CI Man-6-P receptor (IGF2R) | Target Info | Modulator | [2], [3] |
| KEGG Pathway | Lysosome | |||
| Panther Pathway | Apoptosis signaling pathway | |||
| Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | ||||
| Insulin/IGF pathway-protein kinase B signaling cascade | ||||
| Reactome | Golgi Associated Vesicle Biogenesis | |||
| WikiPathways | miR-targeted genes in muscle cell - TarBase | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in leukocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| miR-targeted genes in adipocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00984516) Investigation Into the Safety and Scar-improvement Efficacy of Intradermal Juvidex Dosed Once or Three Times. U.S. National Institutes of Health. | |||
| REF 2 | Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies. Mol Med. 2011 Jan-Feb; 17(1-2): 113-125. | |||
| REF 3 | Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-beta1. Am J Physiol Renal Physiol.2011 Jul;301(1):F84-93. | |||
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