Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00VUL
|
|||
| Former ID |
DIB011903
|
|||
| Drug Name |
Phenazopyridine
|
|||
| Synonyms |
phenazopyridine; Pyridiate; Gastracid; 94-78-0; Baridium; Pyrazofen; Urogesic; 3-(Phenylazo)-2,6-pyridinediamine; Geridium; Gastrotest; Viridium; 2,6-Pyridinediamine, 3-(phenylazo)-; Pyridacil; Fenazopiridina; Eridium; 2,6-Diamino-3-phenylazopyridine; Phenazopyridinum; 2,6-Diamino-3-(phenylazo)pyridine; Phenazopyridine [INN:BAN]; UNII-K2J09EMJ52; Phenazopyridinum [INN-Latin]; Fenazopiridina [INN-Spanish]; NSC 145895; HSDB 3153; EINECS 202-363-2; BRN 0184497; 3-(phenyldiazenyl)pyridine-2,6-diamine; Pyridine, 2,6-diamino-3-(phenylazo)-
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Pain [ICD-11: MG30-MG3Z] | Approved | [1], [2] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C11H11N5
|
|||
| Canonical SMILES |
C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N
|
|||
| InChI |
1S/C11H11N5/c12-10-7-6-9(11(13)14-10)16-15-8-4-2-1-3-5-8/h1-7H,(H4,12,13,14)
|
|||
| InChIKey |
QPFYXYFORQJZEC-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 94-78-0
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
9633, 429038, 631294, 7348356, 10538554, 10986134, 11112296, 11335986, 11361225, 11363907, 11366469, 11369031, 11371787, 11374087, 11377193, 11462197, 11466780, 11467900, 11483789, 11486439, 11487833, 11490360, 11492289, 11494827, 14748951, 29223840, 46507962, 47211772, 47216813, 47216814, 47440304, 47515353, 47810793, 47959790, 48416404, 49698630, 50032107, 50100844, 57322430, 60914066, 80675658, 85788784, 92712625, 92763268, 96025033, 103378408, 104171363, 104307334, 107890263, 117528062
|
|||
| ChEBI ID |
CHEBI:71416
|
|||
| ADReCS Drug ID | BADD_D01745 ; BADD_D01746 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Alistipes indistinctus DSM22520
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -8.69; p = 0.011). | |||
|
Studied Microbe: Bacteroides cellulosilyticus DSM 14838
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -7.961; p = 0.002). | |||
|
Studied Microbe: Bacteroides dorei DSM 17855
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -7.888; p = 0.017). | |||
|
Studied Microbe: Bacteroides finegoldii DSM17565
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -6.59; p = 0.008). | |||
|
Studied Microbe: Bacteroides fragilis ATCC43859
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -10.173; p = 0.009). | |||
|
Studied Microbe: Bacteroides fragilis HMW 610
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -10.103; p = 0.012). | |||
|
Studied Microbe: Bacteroides fragilis HMW 615
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -7.037; p = 0.018). | |||
|
Studied Microbe: Bacteroides fragilis NCTC 9343
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -9.536; p = 0.01). | |||
|
Studied Microbe: Bacteroides fragilis str. 3397 T10
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -2.225; p = 0.008). | |||
|
Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -8.11; p = 0.006). | |||
|
Studied Microbe: Bacteroides fragilis str. DS-208
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -8.19; p = 0.007). | |||
|
Studied Microbe: Bacteroides intestinalis DSM 17393
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -6.98; p = 0.003). | |||
|
Studied Microbe: Bacteroides ovatus ATCC 8483
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -1.08; p = 0.025). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 3731
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -3.153; p = 0.008). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 7330
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -1.479; p = 0.022). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -1.792; p = 0.004). | |||
|
Studied Microbe: Bacteroides uniformis ATCC 8492
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -8.581; p = 0.008). | |||
|
Studied Microbe: Bacteroides vulgatus ATCC 8482
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -6.886; p = 0.008). | |||
|
Studied Microbe: Bacteroides WH2
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides WH2 (log2FC = -4.086; p = 0.004). | |||
|
Studied Microbe: Bacteroides xylanisolvens DSM18836
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -8.164; p = 0.003). | |||
|
Studied Microbe: Odoribacter splanchnicus
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Odoribacter splanchnicus (log2FC = -6.017; p = 0.013). | |||
|
Studied Microbe: Parabacteroides distasonis ATCC 8503
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -10.047; p = 0.006). | |||
|
Studied Microbe: Parabacteroides johnsonii DSM 18315
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -6.471; p = 0.008). | |||
|
Studied Microbe: Parabacteroides merdae ATCC 43184
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -3.877; p = 0.002). | |||
|
Studied Microbe: Pretovella copri DSM 18205
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Pretovella copri DSM 18205 (log2FC = -10.105; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
|
Studied Microbe: Bifidobacterium breve DSM 20213
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -9.52; p = 0.007). | |||
|
Studied Microbe: Bifidobacterium ruminantium
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bifidobacterium ruminantium (log2FC = -0.589; p = 0.015). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
|
Studied Microbe: Collinsella aerofaciens ATCC25986
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -7.983; p = 0.02). | |||
|
Studied Microbe: Collinsella intestinalis DSM 13280
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -7.825; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
|
Studied Microbe: Eggerthella lenta ATCC 25559
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -2.878; p = 0.011). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
|
Studied Microbe: Proteus penneri ATCC 35198
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Proteus penneri ATCC 35198 (log2FC = -0.4; p = 0.03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
|
Studied Microbe: Clostridium ramosum DSM 1402
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -8.764; p = 0.007). | |||
|
Studied Microbe: Clostridium spiroforme DSM1552
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -4.813; p = 0.008). | |||
|
Studied Microbe: Eubacterium biforme DSM 3989
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -6.729; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Anaerostipes sp.
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Anaerostipes sp. (log2FC = -7.21; p = 0.015). | |||
|
Studied Microbe: Anaerotruncus colihominis DSM 17241
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -6.006; p = 0.012). | |||
|
Studied Microbe: Blautia hansenii DSM20583
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Blautia hansenii DSM20583 (log2FC = -9.178; p = 0.01). | |||
|
Studied Microbe: Blautia luti DSM 14534
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Blautia luti DSM 14534 (log2FC = -8.806; p = 0.011). | |||
|
Studied Microbe: Bryantia formatexigens DSM 14469
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -6.856; p = 0.012). | |||
|
Studied Microbe: Clostridium asparagiforme DSM 15981
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -9.241; p = 0.005). | |||
|
Studied Microbe: Clostridium difficile 120
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Clostridium difficile 120 (log2FC = -8.323; p = 0.011). | |||
|
Studied Microbe: Clostridium hathewayi DSM 13479
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -10.213; p = 0.013). | |||
|
Studied Microbe: Clostridium sp.
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Clostridium sp. (log2FC = -9.136; p = 0.005). | |||
|
Studied Microbe: Clostridium sporogenes ATCC 15579
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -9.071; p = 0.004). | |||
|
Studied Microbe: Clostridium symbiosum ATCC 14940
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -9.719; p = 0.006). | |||
|
Studied Microbe: Coprococcus comes ATCC 27758
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -9.531; p = 0.008). | |||
|
Studied Microbe: Dorea formicigenerans ATCC 27755
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -4.977; p = 0.007). | |||
|
Studied Microbe: Enterocloster bolteae ATCC BAA-613
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -9.715; p = 0.014). | |||
|
Studied Microbe: Eubacterium hallii DSM3353
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Eubacterium hallii DSM3353 (log2FC = -9.243; p = 0.003). | |||
|
Studied Microbe: Eubacterium rectale ATCC 33656
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -8.323; p = 0.012). | |||
|
Studied Microbe: Eubacterium ventriosum ATCC 27560
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -7.719; p = 0.008). | |||
|
Studied Microbe: Roseburia intestinalis L1-82
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Roseburia intestinalis L1-82 (log2FC = -8.878; p = 0.008). | |||
|
Studied Microbe: Ruminococcus gnavus ATCC 29149
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -8.872; p = 0.008). | |||
|
Studied Microbe: Ruminococcus lactaris ATCC 29176
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -8.711; p = 0.007). | |||
|
Studied Microbe: Ruminococcus torques ATCC 27756
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -1.089; p = 0.008). | |||
|
Studied Microbe: Subdoligranulum variabile DSM 15176
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -8.613; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
|
Studied Microbe: Enterococcus faecalis V583
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Enterococcus faecalis V583 (log2FC = -8.578; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
|
Studied Microbe: Anaerococcus hydrogenalis DSM 7454
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -10.094; p = 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
|
Studied Microbe: Victivallis vadensis ATCC BAA-548
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Phenazopyridine can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -2.966; p = 0.018). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7616). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.