Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00UET
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| Former ID |
DIB004208
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| Drug Name |
SAR-407899
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| Synonyms |
ROCK inhibitors, sanofi-aventis; Rho kinase inhibitors, sanofi-aventis
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| Indication | Diabetic nephropathy [ICD-11: GB61.Z; ICD-9: 250.4] | Phase 2 | [1] | |
| Microvascular angina [ICD-11: BA86] | Phase 2 | [2] | ||
| Company |
Sanofi
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| Structure |
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Download2D MOL |
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| Formula |
C14H16N2O2
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| Canonical SMILES |
C1CNCCC1OC2=CC3=C(C=C2)C(=O)NC=C3
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| InChI |
1S/C14H16N2O2/c17-14-13-2-1-12(9-10(13)3-8-16-14)18-11-4-6-15-7-5-11/h1-3,8-9,11,15H,4-7H2,(H,16,17)
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| InChIKey |
IPEXHQGMTHOKQV-UHFFFAOYSA-N
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| CAS Number |
CAS 923359-38-0
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00914277) SAR407899 Single-dose in Treatment of Mild to Moderate Erectile Dysfunction. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. J Hypertens. 2012 May;30(5):980-9. | |||
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