Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00TLD
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| Former ID |
DIB002339
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| Drug Name |
RIG-200
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| Synonyms |
1,3,4,6-Tetra-O-acetyl-2-[2(S)-(acetylamino)-3-methyl-3-(nitrososulfanyl)butyramido]-2-deoxy-beta-D-glucopyranose
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Discontinued in Phase 1 | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C21H31N3O12S
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| Canonical SMILES |
CC(=O)NC(C(=O)NC1C(C(C(OC1OC(=O)C)COC(=O)C)OC(=O)C)OC(=O)C)C(C)(C)SN=O
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| InChI |
1S/C21H31N3O12S/c1-9(25)22-18(21(6,7)37-24-31)19(30)23-15-17(34-12(4)28)16(33-11(3)27)14(8-32-10(2)26)36-20(15)35-13(5)29/h14-18,20H,8H2,1-7H3,(H,22,25)(H,23,30)/t14-,15-,16-,17-,18+,20-/m1/s1
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| InChIKey |
VISYVRBZWPNIOD-GFJCLWMYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Guanylate cyclase soluble beta-1 (GUCY1B1) | Target Info | Modulator | [2] |
| KEGG Pathway | Purine metabolism | |||
| cGMP-PKG signaling pathway | ||||
| Vascular smooth muscle contraction | ||||
| Gap junction | ||||
| Platelet activation | ||||
| Circadian entrainment | ||||
| Long-term depression | ||||
| Oxytocin signaling pathway | ||||
| Salivary secretion | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| Panther Pathway | Endothelin signaling pathway | |||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | Nitric oxide stimulates guanylate cyclase | |||
| WikiPathways | Platelet homeostasis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011948) | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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