Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00TGR
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| Former ID |
DNAP001697
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| Drug Name |
Citric acid, magnesium oxide, sodium picosulfate
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| Synonyms |
Prepopik (TN)
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| Drug Type |
Small molecular drug
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| Indication | Crohn disease [ICD-11: DD70; ICD-10: K50, K50.9] | Approved | [1] | |
| Company |
Ferring Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H13NNa2O8S2
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| Canonical SMILES |
C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]
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| InChI |
1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2
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| InChIKey |
GOZDTZWAMGHLDY-UHFFFAOYSA-L
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| CAS Number |
CAS 10040-45-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:32147
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| SuperDrug ATC ID |
A02AA02; A06AD02; A12CC10
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [2] | |||
| Resulting Metabolite | 4,4'-dihydroxydiphenyl-(2-pyridyl)-methane; m-hydroxyphenylacetic acid | |||
| Metabolic Effect | Increase activity | |||
| Description | Sodium picosulfate can be metabolized to 4,4'-dihydroxydiphenyl-(2-pyridyl)-methane and m-hydroxyphenylacetic acid by gut microbiota, which results in the increase of the drug's activity. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 2 | The metabolic effect of gut microbiota on drugs. Drug Metab Rev. 2020 Feb;52(1):139-156. | |||
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