Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00QUZ
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| Former ID |
DIB008874
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| Drug Name |
TTP-814
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| Synonyms |
PTP-1B inhibitors (oral, type 2 diabetes), TransTech Pharma
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| Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Phase 1/2 | [1] | |
| Company |
TransTech Pharma Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein-tyrosine phosphatase 1B (PTP1B) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Adherens junction | |||
| Insulin signaling pathway | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Panther Pathway | Cadherin signaling pathway | |||
| Pathway Interaction Database | Insulin Pathway | |||
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | ||||
| Signaling events mediated by PTP1B | ||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||||
| Signaling events mediated by TCPTP | ||||
| IGF1 pathway | ||||
| EGF receptor (ErbB1) signaling pathway | ||||
| Posttranslational regulation of adherens junction stability and dissassembly | ||||
| PDGFR-beta signaling pathway | ||||
| N-cadherin signaling events | ||||
| Reactome | Integrin alphaIIb beta3 signaling | |||
| Regulation of IFNG signaling | ||||
| Regulation of IFNA signaling | ||||
| Growth hormone receptor signaling | ||||
| WikiPathways | Insulin Signaling | |||
| Growth hormone receptor signaling | ||||
| Leptin signaling pathway | ||||
| Interferon gamma signaling | ||||
| Interferon alpha/beta signaling | ||||
| Integrin alphaIIb beta3 signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021204) | |||
| REF 2 | Protein tyrosine phosphatase 1B (PTP-1B; PTPN1). SciBX 5(7); doi:10.1038/scibx.2012.176. Feb. 16 2012 | |||
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