Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00QIA
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| Former ID |
DNC006244
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| Drug Name |
(S)-tert-butyl 4-methyl-1-oxopentan-2-ylcarbamate
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| Synonyms |
58521-45-2; TERT-BUTYL (S)1-FORMYL-3-METHYLBUTYLCARBAMATE; Boc-Leucinal; N-t-butoxycarbonyl-L-leucinal; CHEMBL96823; N-Boc-2(S)-2-amino-4-methyl-pentanal; tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate; Boc-Leu-H; Boc--L--Leucinal; (S)-Boc-Leucinal; t-Boc-Leu-H; BOC-L-LEUCINAL; BOC-LEU-CHO; AC1L2WGL; N--BOC--L--leucinal; t-butoxycarbonyl-L-leucinal; tert-butyl (1S)-1-formyl-3-methylbutylcarbamate; tert-butyloxycarbonyl-leucinal; SCHEMBL739719; N-tert-butoxycarbonyl-L-leucinal; (t-Butyloxycarbonyl)-L-Leucinal
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H21NO3
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| Canonical SMILES |
CC(C)CC(C=O)NC(=O)OC(C)(C)C
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| InChI |
1S/C11H21NO3/c1-8(2)6-9(7-13)12-10(14)15-11(3,4)5/h7-9H,6H2,1-5H3,(H,12,14)/t9-/m0/s1
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| InChIKey |
RQSBRFZHUKLKNO-VIFPVBQESA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathepsin K (CTSK) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Lysosome | |||
| Osteoclast differentiation | ||||
| Toll-like receptor signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| Trafficking and processing of endosomal TLR | ||||
| MHC class II antigen presentation | ||||
| WikiPathways | RANKL/RANK Signaling Pathway | |||
| Osteoclast Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. | |||
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