Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00QHT
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| Former ID |
DIB011028
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| Drug Name |
AK-295
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| Synonyms |
Vasolex; AK-265; AK-275; CX-295; Calpain inhibitors (neuropathy); Calpain inhibitors (neuropathy), AxoTect; Calpain inhibitors, Cortex/Alkermes
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| Drug Type |
Small molecular drug
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| Indication | Cerebral infarction [ICD-11: 8B11.5Z; ICD-10: I63] | Terminated | [1] | |
| Company |
Alkermes Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C26H40N4O6
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| Canonical SMILES |
CCC(C(=O)C(=O)NCCCN1CCOCC1)NC(=O)C(CC(C)C)NC(=O)OCC2=CC=CC=C2
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| InChI |
1S/C26H40N4O6/c1-4-21(23(31)25(33)27-11-8-12-30-13-15-35-16-14-30)28-24(32)22(17-19(2)3)29-26(34)36-18-20-9-6-5-7-10-20/h5-7,9-10,19,21-22H,4,8,11-18H2,1-3H3,(H,27,33)(H,28,32)(H,29,34)/t21?,22-/m0/s1
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| InChIKey |
TZVQRMYLYQNBOA-KEKNWZKVSA-N
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| CAS Number |
CAS 160399-35-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calpain-2 (CAPN2) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Protein processing in endoplasmic reticulum | |||
| Apoptosis | ||||
| Alzheimer's disease | ||||
| Reactome | Degradation of the extracellular matrix | |||
| WikiPathways | Focal Adhesion | |||
| Integrated Pancreatic Cancer Pathway | ||||
| Alzheimers Disease | ||||
| Integrin-mediated Cell Adhesion | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007674) | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2336). | |||
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