Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00QAR
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| Former ID |
DNC000302
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| Drug Name |
Benzylpenicillin
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| Synonyms |
penicillin g; Benzylpenicillinic acid; Free penicillin II; Pencillin G; 61-33-6; Benzylpenicillin G; Bencilpenicilina; Benzylpenicillinum; Benzyl penicillin; Free penicillin G; Dropcillin; Pharmacillin; Gelacillin; Liquacillin; Benzopenicillin; Cilopen; Pradupen; Benzylpenicilline; Specilline G; Cilloral; Cosmopen; Ursopen; Galofak; Free benzylpenicillin; Compocillin G; Phenylacetamidopenicillanic acid; 6-(2-Phenylacetamido)penicillanic acid; Pfizerpen; Benzyl-6-aminopenicillinic acid
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H18N2O4S
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| Canonical SMILES |
CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C
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| InChI |
1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1
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| InChIKey |
JGSARLDLIJGVTE-MBNYWOFBSA-N
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| CAS Number |
CAS 61-33-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7885, 617709, 820202, 841337, 7849395, 7889969, 7980271, 8144852, 8153657, 11335491, 11360730, 11363827, 11366389, 11368951, 11371783, 11374081, 11377113, 11461702, 11467106, 11468226, 11484211, 11486734, 11488334, 11490358, 11492286, 11494747, 14875396, 15348041, 26711903, 29215263, 29224931, 46506778, 47291043, 47365102, 47588906, 47736376, 48035012, 48184904, 48184905, 49647119, 50050765, 53787815, 57323037, 57588014, 79379468, 81066337, 81093162, 85244562, 85788897, 85789209
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| ChEBI ID |
CHEBI:18208
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| ADReCS Drug ID | BADD_D01710 ; BADD_D02435 | |||
| SuperDrug ATC ID |
J01CE01; S01AA14
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| SuperDrug CAS ID |
cas=000061336
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Benzathine benzylpenicillin (adjusted p-values: 3.94E-05). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Benzathine benzylpenicillin (adjusted p-values: 2.89E-04). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Benzathine benzylpenicillin (adjusted p-values: 9.07E-04). | |||
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Studied Microbe: Bacteroides ovatus
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Benzathine benzylpenicillin (adjusted p-values: 1.66E-03). | |||
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Studied Microbe: Bacteroides uniformis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Benzathine benzylpenicillin (adjusted p-values: 1.50E-06). | |||
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Studied Microbe: Bacteroides vulgatus
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Benzathine benzylpenicillin (adjusted p-values: 4.01E-06). | |||
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Studied Microbe: Odoribacter splanchnicus
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Parabacteroides distasonis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Benzathine benzylpenicillin (adjusted p-values: 2.73E-07). | |||
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Studied Microbe: Parabacteroides merdae
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Benzathine benzylpenicillin (adjusted p-values: 4.93E-07). | |||
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Studied Microbe: Prevotella copri
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.78E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bifidobacterium longum
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium longum was decreased by Benzathine benzylpenicillin (adjusted p-values: 7.40E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Benzathine benzylpenicillin (adjusted p-values: 3.25E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.86E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.53E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Benzathine benzylpenicillin (adjusted p-values: 7.48E-07). | |||
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Studied Microbe: Clostridioides difficile
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Benzathine benzylpenicillin (adjusted p-values: 6.16E-06). | |||
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Studied Microbe: Clostridium perfringens
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Coprococcus comes
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Dorea formicigenerans
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Eubacterium eligens
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Benzathine benzylpenicillin (adjusted p-values: 1.99E-05). | |||
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Studied Microbe: Eubacterium rectale
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Benzathine benzylpenicillin (adjusted p-values: 1.04E-03). | |||
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Studied Microbe: Lacrimispora saccharolytica
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Benzathine benzylpenicillin (adjusted p-values: 2.73E-07). | |||
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Studied Microbe: Roseburia hominis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Benzathine benzylpenicillin (adjusted p-values: 6.74E-05). | |||
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Studied Microbe: Roseburia intestinalis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Benzathine benzylpenicillin (adjusted p-values: 6.07E-04). | |||
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Studied Microbe: Ruminococcus bromii
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Benzathine benzylpenicillin (adjusted p-values: 1.50E-05). | |||
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Studied Microbe: Ruminococcus gnavus
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Ruminococcus torques
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Benzathine benzylpenicillin (adjusted p-values: 2.05E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus paracasei
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lactobacillus paracasei was decreased by Benzathine benzylpenicillin (adjusted p-values: 1.89E-05). | |||
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Studied Microbe: Streptococcus parasanguinis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Benzathine benzylpenicillin (adjusted p-values: 7.08E-07). | |||
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Studied Microbe: Streptococcus salivarius
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.51E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
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Studied Microbe: Veillonella parvula
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Veillonella parvula was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Akkermansia muciniphila was decreased by Benzathine benzylpenicillin (adjusted p-values: 5.84E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
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Studied Microbe: Firmicutes
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Firmicutes was decreased by Penicillin G. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Penicillin binding protein 1 (Bact pbp) | Target Info | Binder | [3] |
| Bacterial Penicillin binding protein 3 (Bact mrcA) | Target Info | Binder | [4] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 2 | From the Cover: Exposure to Oral Antibiotics Induces Gut Microbiota Dysbiosis Associated with Lipid Metabolism Dysfunction and Low-Grade Inflammation in Mice. Toxicol Sci. 2016 Nov;154(1):140-152. | |||
| REF 3 | Overexpression, purification and biochemical characterization of a class A high-molecular-mass penicillin-binding protein (PBP), PBP1* and its soluble derivative from Mycobacterium tuberculosis. Biochem J. 2002 Feb 1;361(Pt 3):635-9. | |||
| REF 4 | Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother. 2001 Jun;45(6):1693-9. | |||
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